Incomplete<em> Plasmodium falciparum</em> growth inhibition following piperaquine treatment translates into increased parasite viability in the <em>in... (Publications)
, i.e. increased parasite growth at higher drug concentrations. However, the 50% inhibitory concentrations (IC(50)) remain relatively stable across parasite lines. Measuring parasite viability of a dr [...] Cambodian Plasmodium falciparum isolate in a parasite reduction ratio (PRR) assay helped to better understand the resistance phenotype towards PPQ. In this parasite isolate, incomplete growth inhibition translated [...] 5-fold increase in IC(50) but a dramatic decrease of parasite killing in...
Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers (Publications)
virulence of the malaria parasite Plasmodium falciparum is due, in part, to its ability to cytoadhere in deep vascular beds. Our inability to quantify the load of sequestered parasites hampers our understanding [...] peripheral parasite densities in a series of 22 patients with severe Plasmodium falciparum malaria. The markers comprised the host factors: haematocrit, circulating host DNA, sTNF-R75 and parasite derived [...] sTNF-R75 and circulating parasite DNA were most strongly correlated with...
Sushi delights and parasites: the risk of fishborne and foodborne parasitic zoonoses in Asia (Publications)
fishborne parasitic zoonoses, especially anisakiasis. In addition, an array of freshwater and brackish-water fish and wild animal meats, which are important sources of infection with zoonotic parasites, are [...] are served as sushi and sashimi in rural areas of Japan. Such fishborne and foodborne parasitic zoonoses are also endemic in many Asian countries that have related traditional cooking styles. Despite the [...] is to provide practical background information regarding representative...
Parasite-host dynamics throughout antimalarial drug development stages complicate the translation of parasite clearance (Publications)
different relationships of parasite clearance with dose, and different maximum parasite clearance rates: in P. berghei-NMRI mouse infections we estimated a maximum parasite clearance rate of 0.2 [1/h]; [...] we developed a suite of mathematical models to capture parasite growth and drug clearance along the drug development pathway and estimated parasite clearance rates. When comparing the three infection e [...] falciparum, we found a maximum parasite clearance rate of 0.12 [1/h] and 0.18 [1/h]...
Giant host red blood cell membrane mimicking polymersomes bind parasite proteins and malaria parasites (Publications)
malaria parasites into host red blood cells (RBCs) - using polymer vesicle-based (polymersome) nanomimics of RBC membranes - the life cycle of the parasite is interrupted and the exposed parasites are accessible [...] with the same block copolymers as nanomimics, also bind the corresponding malaria parasite ligand and whole malaria parasites, similar to nanomimics. This was demonstrated using fluorescence imaging techniques
Global impact of parasitic infections and the importance of parasite control (Publications)
Parasites have a severe impact on animal and human health. Parasites like worms, ticks, mites, fleas, biting flies, mosquitoes, and pathogenic protozoa affect humans and their pets as well as their livestock [...] infection. The effective control of parasites in animals can greatly improve their quality of life and is also beneficial for humans; this is threatened by drug-resistant parasite populations. Today's key areas [...] areas for improvement of parasite control are as follows: a)...
Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers (Publications)
virulence of the malaria parasite Plasmodium falciparum is due, in part, to its ability to cytoadhere in deep vascular beds. Our inability to quantify the load of sequestered parasites hampers our understanding [...] peripheral parasite densities in a series of 22 patients with severe Plasmodium falciparum malaria. The markers comprised the host factors: haematocrit, circulating host DNA, sTNF-R75 and parasite derived [...] sTNF-R75 and circulating parasite DNA were most strongly correlated with...
Sushi delights and parasites: the risk of fishborne and foodborne parasitic zoonoses in Asia (Publications)
fishborne parasitic zoonoses, especially anisakiasis. In addition, an array of freshwater and brackish-water fish and wild animal meats, which are important sources of infection with zoonotic parasites, are [...] are served as sushi and sashimi in rural areas of Japan. Such fishborne and foodborne parasitic zoonoses are also endemic in many Asian countries that have related traditional cooking styles. Despite the [...] is to provide practical background information regarding representative...
Giant host red blood cell membrane mimicking polymersomes bind parasite proteins and malaria parasites (Publications)
malaria parasites into host red blood cells (RBCs) - using polymer vesicle-based (polymersome) nanomimics of RBC membranes - the life cycle of the parasite is interrupted and the exposed parasites are accessible [...] with the same block copolymers as nanomimics, also bind the corresponding malaria parasite ligand and whole malaria parasites, similar to nanomimics. This was demonstrated using fluorescence imaging techniques
