Can an airway challenge test predict respiratory diseases? A population-based international study (Publications)
rhinitis (incidence rate ratios of 10.82, 5.53, and 4.84, respectively; all P < .01). A low slope predicted disease occurrence, even in subjects who did not reach a 20% decrease in FEV1 at the cumulative [...] underwent spirometry and methacholine challenge tests both at baseline (1991-1993), when they were 20 to 44 years old, and at follow-up (1999-2002) in the European Community Respiratory Health Survey. [...] cumulative dose of 1 mg of methacholine (PD20 > 1 mg). A decrease in slope over...
Can an airway challenge test predict respiratory diseases? A population-based international study (Publications)
rhinitis (incidence rate ratios of 10.82, 5.53, and 4.84, respectively; all P < .01). A low slope predicted disease occurrence, even in subjects who did not reach a 20% decrease in FEV1 at the cumulative [...] underwent spirometry and methacholine challenge tests both at baseline (1991-1993), when they were 20 to 44 years old, and at follow-up (1999-2002) in the European Community Respiratory Health Survey. [...] cumulative dose of 1 mg of methacholine (PD20 > 1 mg). A decrease in slope over...
Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials (Publications)
tolerated. A high efficacy was observed with triclabendazole administered at 10 mg/kg (16 patients; CR: 67%, ERR: 94%) and 20 mg/kg (4 patients; CR: 75%, ERR: 96%). CONCLUSIONS/SIGNIFICANCE: Artemether, administered [...] following artemether dosing were treated with single 10 mg/kg oral triclabendazole. In case of treatment failure, triclabendazole was re-administered at 20 mg/kg in two divided doses. PRINCIPAL FINDINGS: CRs
Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials (Publications)
tolerated. A high efficacy was observed with triclabendazole administered at 10 mg/kg (16 patients; CR: 67%, ERR: 94%) and 20 mg/kg (4 patients; CR: 75%, ERR: 96%). CONCLUSIONS/SIGNIFICANCE: Artemether, administered [...] following artemether dosing were treated with single 10 mg/kg oral triclabendazole. In case of treatment failure, triclabendazole was re-administered at 20 mg/kg in two divided doses. PRINCIPAL FINDINGS: CRs
Evaluating preservation methods for identifying <em>Anopheles gambiae s.s.</em> and <em>Anopheles arabiensis</em> complex mosquitoes species using... (Publications)
submersion in RNAlater(R) at inverted question mark20 degrees C. Mosquitoes were preserved for 1, 4, 10, 32 or 50 weeks before they were scanned.ResultsStorage at 4 degrees C was the only preservation method that [...] at 4 degrees C, (ii) freezing at inverted question mark20 degrees C, (iii) drying over a silica-gel desiccant, (iv) submersion in RNAlater(R) at room temperature, (v) submersion in RNAlater(R) at 4 degrees
Evaluating preservation methods for identifying <em>Anopheles gambiae s.s.</em> and <em>Anopheles arabiensis</em> complex mosquitoes species using... (Publications)
submersion in RNAlater(R) at inverted question mark20 degrees C. Mosquitoes were preserved for 1, 4, 10, 32 or 50 weeks before they were scanned.ResultsStorage at 4 degrees C was the only preservation method that [...] at 4 degrees C, (ii) freezing at inverted question mark20 degrees C, (iii) drying over a silica-gel desiccant, (iv) submersion in RNAlater(R) at room temperature, (v) submersion in RNAlater(R) at 4 degrees
Novel 1-methyl-1 <em>H</em>-pyrazole-5-carboxamide derivatives with potent anthelmintic activity (Publications)
analogues of their hybrid structure. Compounds 10, 17, 20, and 22 were identified as the most potent compounds, inhibiting the development of the fourth larval (L4) stage of H. contortus at sub-nanomolar potencies [...] potencies while displaying strong selectivity toward the parasite when tested in vitro against the human MCF10A cell line. In addition, compounds 9 and 27 showed promising activity against a panel of other parasitic
Novel 1-methyl-1 <em>H</em>-pyrazole-5-carboxamide derivatives with potent anthelmintic activity (Publications)
analogues of their hybrid structure. Compounds 10, 17, 20, and 22 were identified as the most potent compounds, inhibiting the development of the fourth larval (L4) stage of H. contortus at sub-nanomolar potencies [...] potencies while displaying strong selectivity toward the parasite when tested in vitro against the human MCF10A cell line. In addition, compounds 9 and 27 showed promising activity against a panel of other parasitic
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial (Publications)
primary care facilities. Over 11 months, 23,593 consultations were included from 20 ePOCT+ health facilities and 20,713 from 20 usual care facilities. The use of ePOCT+ in intervention facilities resulted [...] outcome of antibiotic prescription compared to usual care (23.2% versus 70.1%, adjusted difference -46.4%, 95% confidence interval (CI) -57.6 to -35.2). The coprimary outcome of day 7 clinical failure was [...] ePOCT+ facilities compared to usual care facilities (adjusted relative risk...
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial (Publications)
primary care facilities. Over 11 months, 23,593 consultations were included from 20 ePOCT+ health facilities and 20,713 from 20 usual care facilities. The use of ePOCT+ in intervention facilities resulted [...] outcome of antibiotic prescription compared to usual care (23.2% versus 70.1%, adjusted difference -46.4%, 95% confidence interval (CI) -57.6 to -35.2). The coprimary outcome of day 7 clinical failure was [...] ePOCT+ facilities compared to usual care facilities (adjusted relative risk...
