Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar states (Publications)
hypertonic saline. Median plasma copeptin concentrations decreased from 3.3 (1.1-36.4) pm at baseline to 2.0 (0.9-10.4) pm after water load and increased to 13.6 (3.7-43.3) pm after hypertonic saline. [...] hyperosmolar states. Methods: Plasma osmolalities, copeptin, and vasopressin levels were measured in 20 volunteers at baseline, after an oral water load, and during and after iv infusion of 3% saline. C
Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar states (Publications)
hypertonic saline. Median plasma copeptin concentrations decreased from 3.3 (1.1-36.4) pm at baseline to 2.0 (0.9-10.4) pm after water load and increased to 13.6 (3.7-43.3) pm after hypertonic saline. [...] hyperosmolar states. Methods: Plasma osmolalities, copeptin, and vasopressin levels were measured in 20 volunteers at baseline, after an oral water load, and during and after iv infusion of 3% saline. C
Diarrhoeagenic <em>E. coli </em>occurrence and antimicrobial resistance of extended spectrum beta-lactamases isolated from diarrhoea patients... (Publications)
with an overall ESBL occurrence of 20.4% (20/98), predominantly among E. coli showed 13.2% (10/76), Klebsiella pneumoniae,35.7%(5/14) and Proteus mirabilis, 57.1%(4/7). Among the ESBL genes detected, blaTEM [...] blaTEM (n = 14) was common, followed by blaCTX-M (n = 13) and blaSHV (n = 4). Thirty-four E. coli isolates possessed the heat labile (Lt) gene of Enterotoxigenic E. coli (ETEC). CONCLUSION: Our findings
Diarrhoeagenic <em>E. coli </em>occurrence and antimicrobial resistance of extended spectrum beta-lactamases isolated from diarrhoea patients... (Publications)
with an overall ESBL occurrence of 20.4% (20/98), predominantly among E. coli showed 13.2% (10/76), Klebsiella pneumoniae,35.7%(5/14) and Proteus mirabilis, 57.1%(4/7). Among the ESBL genes detected, blaTEM [...] blaTEM (n = 14) was common, followed by blaCTX-M (n = 13) and blaSHV (n = 4). Thirty-four E. coli isolates possessed the heat labile (Lt) gene of Enterotoxigenic E. coli (ETEC). CONCLUSION: Our findings
Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against... (Publications)
albendazole plus ivermectin, 10 (9.3%) for albendazole plus mebendazole, 20 (18.2%) for albendazole plus oxantel pamoate, and 16 (14.5%) for mebendazole; headaches were reported by 5 (4.6%) children for albendazole [...] mebendazole alone (nine of 107 cured [8.4%, 3.1-13.8]; egg reduction 58.5%, 45.2-70.9). Albendazole plus mebendazole had similar low efficacy (nine of 107 cured [8.4%, 3.1-13.8; egg reduction 51.6%, 35.0-65 [...] albendazole plus ivermectin, 6 (5.6%) for albendazole plus...
Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against... (Publications)
albendazole plus ivermectin, 10 (9.3%) for albendazole plus mebendazole, 20 (18.2%) for albendazole plus oxantel pamoate, and 16 (14.5%) for mebendazole; headaches were reported by 5 (4.6%) children for albendazole [...] mebendazole alone (nine of 107 cured [8.4%, 3.1-13.8]; egg reduction 58.5%, 45.2-70.9). Albendazole plus mebendazole had similar low efficacy (nine of 107 cured [8.4%, 3.1-13.8; egg reduction 51.6%, 35.0-65 [...] albendazole plus ivermectin, 6 (5.6%) for albendazole plus...
Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes (Publications)
to 9.65 muM vs 2.20 muM for PZQ). Three of these, which are bisquinoline derivative of cyclen and its Fe2+- and Mn2+-complexes, showed micromolar IC50 values (1.62 muM, 1.34 muM and 4.12 muM, respectively [...] respectively vs 0.10 muM for PZQ) against adult worms. In vivo, the worm burden reductions were 12.3%, 88.4% and 74.8%, respectively at a 400 mg/kg single oral dose. The Fe2+-complex exhibited activity in vivo [...] compounds resulted in mortality of NTS at the 61% to 100% level. Five of...
Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes (Publications)
to 9.65 muM vs 2.20 muM for PZQ). Three of these, which are bisquinoline derivative of cyclen and its Fe2+- and Mn2+-complexes, showed micromolar IC50 values (1.62 muM, 1.34 muM and 4.12 muM, respectively [...] respectively vs 0.10 muM for PZQ) against adult worms. In vivo, the worm burden reductions were 12.3%, 88.4% and 74.8%, respectively at a 400 mg/kg single oral dose. The Fe2+-complex exhibited activity in vivo [...] compounds resulted in mortality of NTS at the 61% to 100% level. Five of...
Ten-year trends of syphilis in sero-surveillance of pregnant women in Rwanda and correlates of syphilis-HIV co-infection (Publications)
Results showed that syphilis decreased from 3.8% in 2002 to 2.0% in 2011. Syphilis in the HIV-infected participants increased from 6.0% in 2002 to 10.8% in 2011, but decreased from 3.7% to 1.7% in the HIV-negative [...] 7% and 1.4% in rural ones. HIV-infected participants screened positive for syphilis more frequently in both rural (aOR = 3.64 [95% CI: 1.56%-8.51%]) and urban areas (aOR = 7.26 [95% CI: 5.04%-10.46%]). Older [...] (aOR = 0.43[95% CI: 0.32%-0.58%]) and women with secondary or high...
Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the <em>Schistosoma mansoni</em> mouse model (Publications)
systemic circulation by ~10 to 20 fold but the latter were not predictive of efficacy. The use of DEX decreased plasma exposures of (R)-PZQ in the systemic circulation by ~10 fold without reducing efficacy [...] inducer, dexamethasone (DEX), was determined. Plasma samples were obtained by tail vein bleeding at 4 time points. The (R)-PZQ levels were determined using a LC-MS/MS method. Non-compartmental pharmacokinetic [...] vein / mesenteric veins from the systemic exposures and found that a free...
