Ten-year trends of syphilis in sero-surveillance of pregnant women in Rwanda and correlates of syphilis-HIV co-infection (Publications)
Results showed that syphilis decreased from 3.8% in 2002 to 2.0% in 2011. Syphilis in the HIV-infected participants increased from 6.0% in 2002 to 10.8% in 2011, but decreased from 3.7% to 1.7% in the HIV-negative [...] 7% and 1.4% in rural ones. HIV-infected participants screened positive for syphilis more frequently in both rural (aOR = 3.64 [95% CI: 1.56%-8.51%]) and urban areas (aOR = 7.26 [95% CI: 5.04%-10.46%]). Older [...] (aOR = 0.43[95% CI: 0.32%-0.58%]) and women with secondary or high...
Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the <em>Schistosoma mansoni</em> mouse model (Publications)
systemic circulation by ~10 to 20 fold but the latter were not predictive of efficacy. The use of DEX decreased plasma exposures of (R)-PZQ in the systemic circulation by ~10 fold without reducing efficacy [...] inducer, dexamethasone (DEX), was determined. Plasma samples were obtained by tail vein bleeding at 4 time points. The (R)-PZQ levels were determined using a LC-MS/MS method. Non-compartmental pharmacokinetic [...] vein / mesenteric veins from the systemic exposures and found that a free...
<em>In silico</em> prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against <em>Trypanosoma brucei... (Publications)
type, goyazensolide, 4,5-dihydro-2' ,3' -epoxy-15-deoxygoyazensolide, budlein A and 4,15-isoatriplicolide tiglate, were therefore tested. They displayed IC50 values of 0.07, 0.20 and 0.07 and 0.015 muM [...] laboratories to 59. On the basis of this extended data set, further enriched by literature data for 10 compounds tested under the same conditions, our QSAR analyses for activity against T. brucei rhodesiense [...] muM, respectively, so that the in silico-prediction was...
<em>In silico</em> prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against <em>Trypanosoma brucei... (Publications)
type, goyazensolide, 4,5-dihydro-2' ,3' -epoxy-15-deoxygoyazensolide, budlein A and 4,15-isoatriplicolide tiglate, were therefore tested. They displayed IC50 values of 0.07, 0.20 and 0.07 and 0.015 muM [...] laboratories to 59. On the basis of this extended data set, further enriched by literature data for 10 compounds tested under the same conditions, our QSAR analyses for activity against T. brucei rhodesiense [...] muM, respectively, so that the in silico-prediction was...
Exposure of highway maintenance workers to fine particulate matter and noise (Publications)
ons (gravimetric measurements) ranged from 20.3 to 321 mug m(-3) (mean 62 mug m(-3)) and PNC were between 1.6x10(4) and 4.1x10(5) particles cm(-3) (8.9x10(4) particles cm(-3)). Noise levels were generally
Excess mortality during the warm summer of 2015 in Switzerland (Publications)
excess deaths (5.4%, 95% confidence interval [CI] 3.07.9%) were estimated for summer 2015 compared with previous summers, with the highest percentage obtained for July (11.6%, 95% CI 3.719.4%). Seventy-seven [...] ven percent of deaths occurred in people aged 75 years and older. Ticino (10.3%, 95% CI -1.822.4%), Northwestern Switzerland (9.5%, 95% CI 2.716.3%) and Espace Mittelland (8.9%, 95% CI 3.714.1%) showed [...] predictions derived from quasi-Poisson regression models fitted to the daily...
Exposure of highway maintenance workers to fine particulate matter and noise (Publications)
ons (gravimetric measurements) ranged from 20.3 to 321 mug m(-3) (mean 62 mug m(-3)) and PNC were between 1.6x10(4) and 4.1x10(5) particles cm(-3) (8.9x10(4) particles cm(-3)). Noise levels were generally
Excess mortality during the warm summer of 2015 in Switzerland (Publications)
excess deaths (5.4%, 95% confidence interval [CI] 3.07.9%) were estimated for summer 2015 compared with previous summers, with the highest percentage obtained for July (11.6%, 95% CI 3.719.4%). Seventy-seven [...] ven percent of deaths occurred in people aged 75 years and older. Ticino (10.3%, 95% CI -1.822.4%), Northwestern Switzerland (9.5%, 95% CI 2.716.3%) and Espace Mittelland (8.9%, 95% CI 3.714.1%) showed [...] predictions derived from quasi-Poisson regression models fitted to the daily...
The burden of leprosy in Cameroon: fifteen years into the post-elimination era (Publications)
prevalence rate of 0.94/10,000 population. The prevalence rate dropped further to reach 0.20/10,000 population (78% reduction) in 2014. Similarly, the new case detection rate dropped from 4.88/100,000 population [...] 1.46/100,000 population (85.3% reduction) in 2014. All 10 regions of the country achieved leprosy elimination between 2000 and 2014; however, 10 health districts were still to do so by 2014. The number
The burden of leprosy in Cameroon: fifteen years into the post-elimination era (Publications)
prevalence rate of 0.94/10,000 population. The prevalence rate dropped further to reach 0.20/10,000 population (78% reduction) in 2014. Similarly, the new case detection rate dropped from 4.88/100,000 population [...] 1.46/100,000 population (85.3% reduction) in 2014. All 10 regions of the country achieved leprosy elimination between 2000 and 2014; however, 10 health districts were still to do so by 2014. The number
