LC-MS/MS method for the determinatin of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and... (Publications)
stable within the autosampler for 72h (10°C), for 4h at room temperature, for 3 month at -80°C, and after three freeze and thaw cycles. DBS samples should be stored at -20°C. The validation results demonstrated [...] mode (dADT: 178.3?133.1m/z, adADT: 220.4?175.1m/z, tribendimidine 294.3?249.0m/z). A pentafluorophenyl (PFP) phase Kinetex analytical column (2.6µm, 100Å, 50mm×4.6mm) with a 6min lasting mobile phase gradient [...] sensitivity, and selectivity. The analytical range in plasma and...
LC-MS/MS method for the determinatin of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and... (Publications)
stable within the autosampler for 72h (10°C), for 4h at room temperature, for 3 month at -80°C, and after three freeze and thaw cycles. DBS samples should be stored at -20°C. The validation results demonstrated [...] mode (dADT: 178.3?133.1m/z, adADT: 220.4?175.1m/z, tribendimidine 294.3?249.0m/z). A pentafluorophenyl (PFP) phase Kinetex analytical column (2.6µm, 100Å, 50mm×4.6mm) with a 6min lasting mobile phase gradient [...] sensitivity, and selectivity. The analytical range in plasma and...
Effectiveness of a peer educator-coordinated preference-based differentiated service delivery model on viral suppression among young people living... (Publications)
FINDINGS: Individuals taking antiretroviral therapy (ART) aged 15 to 24 years at 20 clinics (clusters) were eligible. In the 10 clinics randomized to the intervention arm, participants were offered the PEBRA [...] (PEBRApp). In the 10 control clusters, participants received standard nurse-coordinated care without any service coordination by a PE. The primary endpoint was 12-month viral suppression below 20 copies/mL. Analyses [...] ratio (OR) 1.27; 95% confidence interval [CI] [0.79 to 2.03]; p...
Effectiveness of a peer educator-coordinated preference-based differentiated service delivery model on viral suppression among young people living... (Publications)
FINDINGS: Individuals taking antiretroviral therapy (ART) aged 15 to 24 years at 20 clinics (clusters) were eligible. In the 10 clinics randomized to the intervention arm, participants were offered the PEBRA [...] (PEBRApp). In the 10 control clusters, participants received standard nurse-coordinated care without any service coordination by a PE. The primary endpoint was 12-month viral suppression below 20 copies/mL. Analyses [...] ratio (OR) 1.27; 95% confidence interval [CI] [0.79 to 2.03]; p...
Eleven-year single-center experience with the ATS Open Pivot Bileaflet heart valve (Publications)
endocarditis, 53 (9%); and atrial fibrillation, 115 (20%). RESULTS: Follow-up is 99% complete. Data represent 2,500 cumulative patient-years. Mean follow-up is 4.3 +/- 2.6 years (range, 0.1 to 11.6). Overall [...] follows: AVR, 3.8% (15 patients); MVR, 1.8% (3 patients); DVR, 10% (2 patients). Structural valve failure was not encountered. Overall survival at 10 years is AVR, 84.7% +/- 3.1%, AVR plus coronary artery bypass [...] 8% +/- 7.1%, MVR plus coronary artery bypass, 39% +/- 27.8%; and...
Eleven-year single-center experience with the ATS Open Pivot Bileaflet heart valve (Publications)
endocarditis, 53 (9%); and atrial fibrillation, 115 (20%). RESULTS: Follow-up is 99% complete. Data represent 2,500 cumulative patient-years. Mean follow-up is 4.3 +/- 2.6 years (range, 0.1 to 11.6). Overall [...] follows: AVR, 3.8% (15 patients); MVR, 1.8% (3 patients); DVR, 10% (2 patients). Structural valve failure was not encountered. Overall survival at 10 years is AVR, 84.7% +/- 3.1%, AVR plus coronary artery bypass [...] 8% +/- 7.1%, MVR plus coronary artery bypass, 39% +/- 27.8%; and...
Epidemiology of schistosomiasis in two high-risk communities of south Côte d'Ivoire with particular emphasis on pre-school-aged children (Publications)
study villages among the pre-school-aged children was 20.9% and 25.0%, whereas several-fold higher prevalence was found in school-aged children (58.7-68.4%) and adolescents/adults (59.5-61.7%). The prevalence [...] prevalence of S. haematobium in the three age groups was 5.9-17.3%, 10.9-18.4%, and 3.8-21.3%, respectively. Most participants had light-intensity infections. Mothers' occupations and older siblings play important
Epidemiology of schistosomiasis in two high-risk communities of south Côte d'Ivoire with particular emphasis on pre-school-aged children (Publications)
study villages among the pre-school-aged children was 20.9% and 25.0%, whereas several-fold higher prevalence was found in school-aged children (58.7-68.4%) and adolescents/adults (59.5-61.7%). The prevalence [...] prevalence of S. haematobium in the three age groups was 5.9-17.3%, 10.9-18.4%, and 3.8-21.3%, respectively. Most participants had light-intensity infections. Mothers' occupations and older siblings play important
Safety and efficacy of oral fexinidazole in children with <em>gambiense </em>human African trypanosomiasis: a multicentre, single-arm, open-label,... (Publications)
e of 1200 mg (two x 600 mg tablets) once per day for 4 days (days 1-4) followed by 600 mg (one x 600 mg tablet) once per day for 6 days (days 5-10). Children weighing 35 kg or more received oral fexinidazole [...] of 1800 mg (three x 600 mg tablets) once per day for 4 days (days 1-4), followed by 1200 mg (two x 600 mg tablets) once per day for 6 days (days 5-10). The primary endpoint was fexinidazole treatment success [...] aged 6 years to younger than 15 years, weighing 20 kg or more, and with...
Safety and efficacy of oral fexinidazole in children with <em>gambiense </em>human African trypanosomiasis: a multicentre, single-arm, open-label,... (Publications)
e of 1200 mg (two x 600 mg tablets) once per day for 4 days (days 1-4) followed by 600 mg (one x 600 mg tablet) once per day for 6 days (days 5-10). Children weighing 35 kg or more received oral fexinidazole [...] of 1800 mg (three x 600 mg tablets) once per day for 4 days (days 1-4), followed by 1200 mg (two x 600 mg tablets) once per day for 6 days (days 5-10). The primary endpoint was fexinidazole treatment success [...] aged 6 years to younger than 15 years, weighing 20 kg or more, and with...
