Predictive value of clinical and laboratory features for the main febrile diseases in children living in Tanzania: a prospective observational study (Publications)
performed. RESULTS: 62 variables were studied. Between 4 and 15 significant predictors to rule in (aLR+> 1) or rule out (aLR+ /=40 degrees C (aLR+8.4, 95%CI 4.7-15), for typhoid abdominal tenderness (5.9,2.5-11) [...] 5-11), for urinary tract infection (UTI) age > /=3 years (0.20,0-0.50), for radiological pneumonia abnormal chest auscultation (4.3,2.8-6.1), for acute HHV6 infection dehydration (0.18,0-0.75), for bacterial [...] laboratory workup. METHOD: From April to December 2008, 1005...
Predictive value of clinical and laboratory features for the main febrile diseases in children living in Tanzania: a prospective observational study (Publications)
performed. RESULTS: 62 variables were studied. Between 4 and 15 significant predictors to rule in (aLR+> 1) or rule out (aLR+ /=40 degrees C (aLR+8.4, 95%CI 4.7-15), for typhoid abdominal tenderness (5.9,2.5-11) [...] 5-11), for urinary tract infection (UTI) age > /=3 years (0.20,0-0.50), for radiological pneumonia abnormal chest auscultation (4.3,2.8-6.1), for acute HHV6 infection dehydration (0.18,0-0.75), for bacterial [...] laboratory workup. METHOD: From April to December 2008, 1005...
Response of Kampuchean strains of <em>Plasmodium falciparum</em> to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline;... (Publications)
1.5 g quinine base daily for 10 days the average parasite clearance time was 5.6 days, and the average duration of fever 3.4 days. The in-vivo test was evaluated at 7 and 10 days after the start of therapy [...] by microscopic examination (S); 20 patients had an RI recrudescence, four patients responded at the RII level and three at the RIII level. Evaluating the in-vivo test at 10 days, the number of patients parasite [...] falciparum to quinine plus tetracycline. The course of treatment was:...
Response of Kampuchean strains of <em>Plasmodium falciparum</em> to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline;... (Publications)
1.5 g quinine base daily for 10 days the average parasite clearance time was 5.6 days, and the average duration of fever 3.4 days. The in-vivo test was evaluated at 7 and 10 days after the start of therapy [...] by microscopic examination (S); 20 patients had an RI recrudescence, four patients responded at the RII level and three at the RIII level. Evaluating the in-vivo test at 10 days, the number of patients parasite [...] falciparum to quinine plus tetracycline. The course of treatment was:...
Synthesis, <em>in-vitro</em> antiprotozoal activity and molecular docking study of isothiocyanate derivatives (Publications)
ic activity against Leishmania donovani with IC50 values between 0.4 and 1.0microM and selectivity index (SI) ranged from 7.8 to 18.4, comparable to the standard drug miltefosine (IC50=0.7muM). Compound [...] antileishmanial activity with an IC50 value of 0.4microM. Seven products exhibited inhibition activity against T. brucei rhodesiense with IC50s below 2.0muM and SI between 2.7 and 29.3. Four primary amine [...] 5. The isothiocyanate derivative 7c showed against T. cruzi with an IC50 value...
Synthesis, <em>in-vitro</em> antiprotozoal activity and molecular docking study of isothiocyanate derivatives (Publications)
ic activity against Leishmania donovani with IC50 values between 0.4 and 1.0microM and selectivity index (SI) ranged from 7.8 to 18.4, comparable to the standard drug miltefosine (IC50=0.7muM). Compound [...] antileishmanial activity with an IC50 value of 0.4microM. Seven products exhibited inhibition activity against T. brucei rhodesiense with IC50s below 2.0muM and SI between 2.7 and 29.3. Four primary amine [...] 5. The isothiocyanate derivative 7c showed against T. cruzi with an IC50 value...
Consistency in preventing voluntary dehydration in boys who drink a flavored carbohydrate-NaCl beverage during exercise in the heat (Publications)
Twelve 10- to 12-year-old healthy boys performed six 70-min intermittent exercise sessions (three 20-min cycling bouts at 50% VO2max with 5 min rest in between) over a 2-week period at 35 +/- 1 degrees [...] +/- 5% relative humidity. Subjects drank grape-flavored solution with 6% carbohydrate (2% glucose, 4% sucrose) and 18.0 mmol.L-1 NaCl ad libitum. Body weight (BW), heart rate, rectal temperature, thirst [...] of grape-flavored carbohydrate-NaCl beverage was consistently sufficient to prevent...
Consistency in preventing voluntary dehydration in boys who drink a flavored carbohydrate-NaCl beverage during exercise in the heat (Publications)
Twelve 10- to 12-year-old healthy boys performed six 70-min intermittent exercise sessions (three 20-min cycling bouts at 50% VO2max with 5 min rest in between) over a 2-week period at 35 +/- 1 degrees [...] +/- 5% relative humidity. Subjects drank grape-flavored solution with 6% carbohydrate (2% glucose, 4% sucrose) and 18.0 mmol.L-1 NaCl ad libitum. Body weight (BW), heart rate, rectal temperature, thirst [...] of grape-flavored carbohydrate-NaCl beverage was consistently sufficient to prevent...
Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of <em>Brasenia... (Publications)
methyl gallate (IC(50) 1.1 µg/mL), 2,3,4,6-tetragalloyl-glucopyranoside, ethyl gallate (IC(50) 0.5 µg/mL), 1,2,3,4,6-pentagalloyl-β-glucopyranoside (IC(50) 20 µg/mL), gossypetin-7-O-β-glucopyranoside [...] solvents. A total of 15 extracts from seven different plants exhibited in vitro activity (> 70% at 20 µg/mL) against Trypanosoma brucei rhodesiense bloodstream forms. The dichloromethane extract of Nymphaea [...] (leaves and leaflets) and the ethanolic extract of Brasenia schreberi (leaves)...
Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of <em>Brasenia... (Publications)
methyl gallate (IC(50) 1.1 µg/mL), 2,3,4,6-tetragalloyl-glucopyranoside, ethyl gallate (IC(50) 0.5 µg/mL), 1,2,3,4,6-pentagalloyl-β-glucopyranoside (IC(50) 20 µg/mL), gossypetin-7-O-β-glucopyranoside [...] solvents. A total of 15 extracts from seven different plants exhibited in vitro activity (> 70% at 20 µg/mL) against Trypanosoma brucei rhodesiense bloodstream forms. The dichloromethane extract of Nymphaea [...] (leaves and leaflets) and the ethanolic extract of Brasenia schreberi (leaves)...
