Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet... (Publications)
successful, with no cures (0/2) at 3 mg/kg/day for 10 days and cure rates of 1/4 at 10 mg/kg/day for 10 days and 20 mg/kg/day for 10 days; in total, only 2/10 monkeys were cured with DB868 dose regimens. The [...] DB829 at 5 mg/kg following the last of 5 doses was 25-fold greater than that after 10 daily oral doses of DB868 at 20 mg/kg. These data suggest that the active diamidine DB829, administered IM, should
Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet... (Publications)
successful, with no cures (0/2) at 3 mg/kg/day for 10 days and cure rates of 1/4 at 10 mg/kg/day for 10 days and 20 mg/kg/day for 10 days; in total, only 2/10 monkeys were cured with DB868 dose regimens. The [...] DB829 at 5 mg/kg following the last of 5 doses was 25-fold greater than that after 10 daily oral doses of DB868 at 20 mg/kg. These data suggest that the active diamidine DB829, administered IM, should
Long-term exposure to ambient air pollution and risk of dementia: results of the prospective three-city study (Publications)
sex, education, APOE4 genotype, health behaviours) and contextual (neighbourhood deprivation index) confounders. RESULTS: At baseline, the median age of the 7066 participants was 73.4 years, and 62% were [...] median follow-up duration was 10.0 years during which 791 participants developed dementia (n = 541 Alzheimer's disease (AD) and n = 155 vascular/mixed dementia (VaD)). The 10-year moving average of PM2.5 [...] PM2.5 concentration was positively associated with dementia risk: HR = 1.2...
Reducing ambient levels of fine particulates could substantially improve health: a mortality impact assessment for 26 European cities (Publications)
vs 0.4% reduction) and two times greater than a reduction to 20 microg/m3. The percentage reduction could grow by more than seven times if PM(2.5) levels were reduced to 10 microg/m3 (3.0% vs 0.4%). This [...] all causes that could be prevented by reducing PM(2.5) annual levels to 25 microg/m3, 20 microg/m3, 15 microg/m3 and 10 microg/m3 in 26 European cities. The various PM(2.5) concentrations were chosen as different [...] from the paper by Pope et al (2002). If no direct PM(2.5 )measurements...
Long-term exposure to ambient air pollution and risk of dementia: results of the prospective three-city study (Publications)
sex, education, APOE4 genotype, health behaviours) and contextual (neighbourhood deprivation index) confounders. RESULTS: At baseline, the median age of the 7066 participants was 73.4 years, and 62% were [...] median follow-up duration was 10.0 years during which 791 participants developed dementia (n = 541 Alzheimer's disease (AD) and n = 155 vascular/mixed dementia (VaD)). The 10-year moving average of PM2.5 [...] PM2.5 concentration was positively associated with dementia risk: HR = 1.2...
Reducing ambient levels of fine particulates could substantially improve health: a mortality impact assessment for 26 European cities (Publications)
vs 0.4% reduction) and two times greater than a reduction to 20 microg/m3. The percentage reduction could grow by more than seven times if PM(2.5) levels were reduced to 10 microg/m3 (3.0% vs 0.4%). This [...] all causes that could be prevented by reducing PM(2.5) annual levels to 25 microg/m3, 20 microg/m3, 15 microg/m3 and 10 microg/m3 in 26 European cities. The various PM(2.5) concentrations were chosen as different [...] from the paper by Pope et al (2002). If no direct PM(2.5 )measurements...
): 15.09.–10.10.2025 Face-to-face week: 13.–17.10.2025 Post phase (self-directed): 20.10. –28.11.2025 13.10.2025 - 24.10.2025 IZGG: Geographische Medizin Location: Swiss TPH, Seminar Room 4 Event category: [...] 09.–17.10.2025 Hybrid face-to-face week: 20.–24.10.2025 Post phase (self-directed): 27.10.–05.12.2025 27.10.2025 - 07.11.2025 IZGG: Gesundheitsinterventionen Location: Swiss TPH, Seminar Room 4 Event category: [...] Module B 16.10.2025 Diagnostic en parasitologie médicale: Parasitoses...
Tanzanian Adults, Claudia Daubenberger, Swiss TPH 10:00 Influence of Helminths on Cognition and Physical Activity, Markus Gerber, University of Basel 10:20 Coffee Break Session 6 – Helminth Transmission Chairs: [...] History and Swiss TPH, Hanspeter Marti, Swiss TPH 10:00 Coffee Break Session 2 – Helminth Diagnosis Chairs: J. Keiser and P. Odermatt, Swiss TPH 10:30 Coprological Methods, Bruno Levecke, Ghent University [...] Chairs: S. Knopp and H. Marti, Swiss TPH 10:50 Breaking the Schistosome...
Long-term benefits and limitations of combined antianginal drug therapy in elderly patients with symptomatic chronic coronary artery disease (Publications)
class 4 angina (37% vs 20%, P < 0.05) but reported less prior heart failure (5% vs 20%, P < 0.01), fewer prior cerebral events (3% vs 13%, P < .05) and a lower rate of two or more comorbidities (10% vs 33% [...] DRUG compared to REVASC patients (CCS class, 1.8 +/- 1.6 vs 1.0 +/- 1.4, P < .05) despite more antianginal drugs (2.1 +/- 1.1 vs 1.5 +/- 1.0, P < .01), whereas measures of QOL had improved similarly in [...] years old with Canadian Cardiovascular Society (CCS) class angina 3.0 +/- 0.7...
Long-term benefits and limitations of combined antianginal drug therapy in elderly patients with symptomatic chronic coronary artery disease (Publications)
class 4 angina (37% vs 20%, P < 0.05) but reported less prior heart failure (5% vs 20%, P < 0.01), fewer prior cerebral events (3% vs 13%, P < .05) and a lower rate of two or more comorbidities (10% vs 33% [...] DRUG compared to REVASC patients (CCS class, 1.8 +/- 1.6 vs 1.0 +/- 1.4, P < .05) despite more antianginal drugs (2.1 +/- 1.1 vs 1.5 +/- 1.0, P < .01), whereas measures of QOL had improved similarly in [...] years old with Canadian Cardiovascular Society (CCS) class angina 3.0 +/- 0.7...
