Bioactives
Drug discovery for tropical diseases is one of the research foci of the Swiss TPH. We have developed a wide range of in vitro assays and in vivo models to identify novel chemical hits and to guide hit-to-lead development. Our credo is to always test against the relevant pathogen species and stage, rather than using surrogate models. The success of this approach is illustrated by the fact that several of the therapies that are currently undergoing clinical testing have been developed with the help of our drug discovery platform. Breakthroughs that were achieved in collaboration with the Swiss TPH include novel treatments for Buruli ulcer, human African trypanosomiasis, malaria and soil-transmitted helminths.
Available Drug Efficacy Tests According to Pathogen Species
Bacteria | ||
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Mycobacterium ulcerans | in vitro assays | in vivo assays |
Protozoa | ||
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Babesia divergens | in vitro assays | |
Babesia microti | in vivo assays | |
Entamoeba histolytica | in vitro assays | |
Giardia intestinalis | in vitro assays | |
Leishmania donovani | in vitro assays | |
Leishmania infantum | in vitro assays | |
Plasmodium falciparum | in vitro assays | in vivo assays |
Plasmodium berghei | ex vivo | in vivo assays |
Trypanosoma brucei brucei | in vitro assays | in vivo assays |
Trypanosoma brucei rhodesiense | in vitro assays | in vivo assays |
Trypanosoma brucei gambiense | in vitro assays | in vivo assays |
Trypanosoma congolense | in vitro assays | in vivo assays |
Trypanosoma cruzi | in vitro assays | |
Trypanosoma evansi | in vitro assays | in vivo assays |
Trypanosoma vivax | ex vivo assays | in vivo assays |
Helminths | ||
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Ancylostoma ceylanicum | in vitro assays | in vivo assays |
Echinostoma caproni | in vitro assays | in vivo assays |
Fasciola hepatica | in vitro assays | in vivo assays |
Heligmosomoides polygyrus | in vitro assays | in vivo assays |
Necator americanus | in vitro assays | in vivo assays |
Schistosoma mansoni | in vitro assays | in vivo assays |
Schistosoma haematobium | in vitro assays | in vivo assays |
Trichuris muris | in vitro assays | in vivo assays |
Divers | ||
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several cell lines of Cytotox | in vitro assays |
Range of Arthropod Colonies
We rear a range of mosquito colonies and undertake bioassays in our Arthropod Testing Facility.
Aedes aegypti |
Anopheles gambiae s.s. |
Anopheles stephensi |
Culex quinquefasciatus |
Ornithodoros moubata |
Contacts



