Group | Cancer Disparities

Cancer is the leading cause of morbidity and mortality: about 1 in 5 people will develop cancer in their lifetime (WHO). The causes of cancer are multifactorial and most cancer deaths are avoidable, either by prevention or treatment. Stark cancer inequities exist within and between regions, disproportionally affecting socially and socio-economically disadvantaged people. The Cancer Disparities group conducts high quality research at the intersection of cancer and HIV on a global scale.

Our research activities span from assessing the burden of cancer in populations living with HIV, to improving quality of and access to health care as well as to critically assessing and synthesising the evidence for cancer prevention and treatment. We use probabilistic record linkage methods to bridge data silos from routine care, to inform cancer incidence, risk factors and access to care in people living with HIV. We conduct diagnostic test accuracy studies to determine the accuracy of screening methods for cervical pre-cancer in women living with HIV in low-resource settings. Our work informs clinical and public health practice through clinical guidelines and policy briefs.

For this purpose, we collaborate with international partners in South Africa (National Cancer Registry), Zambia (Centre for Infectious Disease Research in Zambia, CIDRZ) and Tanzania (Ifakara Health Institute), as well as international research organisations. We also work with partners in Mozambique, Zimbabwe, Cameroon, Burkina Faso, Côte d’Ivoire, Nigeria, Republic of Congo, Democratic Republic of Congo, Uganda, Rwanda, Burundi, Malawi, Mozambique and Lesotho.

We strengthen capacity by training PhD students jointly supervised by Swiss TPH staff and international partners, and we foster mutual learning through joint teaching and training activities.

Our research generates impact at clinical and public health level and our group members have received awards and prizes for their research.

Julia Bohlius

Julia Bohlius

MD MScPH, Prof. Dr. med.

Framework for Cervical Cancer Prevention and Care Cascade in Women Living with HIV

Cervical cancer is the leading cause ofcancer related deaths among women in sub-Saharan Africa. Women living with the human immunodeficiency virus (HIV) are six times more likely to develop cervical cancer than those who are HIV negative. To tackle this issue, the Cervical Cancer Prevention and Care Cascade framework has been developed to enhance cervical cancer screening programmes for women living with HIV in sub-Saharan Africa. Read more

Cervical cancer screening in African clinic. Photo credits: CIDRZ

South African Cervical Cancer Screening Cohort

Screening for cervical pre-cancer is available in South Africa, but there is no systematic approach to monitoring and improving screening efforts. The project will establish a comprehensive cohort study by linking data on cervical pre-cancer screening, diagnosis and treatment from the National Health Laboratory System (NHLS) and cancer records from the National Cancer Registry (NCR) in South Africa to assess the provision of and access to cervical cancer screening among women living in South Africa. The results of the study will help improve cervical cancer control programmes in South Africa and other countries in the region. Read more

Cervical cancer is the most common cancer and leading cause of cancer-related mortality in Tanzanian women.

Transdisciplinary Science for Smarter Implementation Strategies

The TRACCTION study aims to understand the cancer landscape in Tanzania and contribute to the elemination of cervical cancer in the country. The mixed-methods study uses a transdisciplinary approach to explore women's perceptions of cervical cancer care, document the cervical cancer care cascade from screening to treatment for women living with and without HIV, and identify demand-side gaps and opportunities to increase uptake of cervical cancer screening and treatment in Kilombero District, Tanzania. Read more

Bürkin B.M et al. Competencies for transformational leadership in public health: an international delphi consensus study. Int J of Public Health. 2024;69:1606267. DOI: 10.3389/ijph.2024.1606267

Davidović M et al. Facility-based indicators to manage and scale up cervical cancer prevention and care services for women living with hiv in sub-Saharan Africa: a three-round online Delphi consensus method. J Acquir Immune Defic Syndr. 2024;95(2):170-178. DOI: 10.1097/qai.0000000000003343

Davidović M, Dhokotera T, Dos-Santos-Silva I, Bohlius J, Sengayi-Muchengeti M. Breast cancer in women by HIV status: a report from the South African National Cancer Registry. PLoS One. 2024;19(6):e0305274. DOI: 10.1371/journal.pone.0305274

Dhokotera T.G et al. Gynaecologic and breast cancers in women living with HIV in South Africa: a record linkage study. Int J Cancer. 2024;154(2):284-296. DOI: 10.1002/ijc.34712

Engels E.A et al. State of the science and future directions for research on HIV and cancer: summary of a joint workshop sponsored by IARC and NCI. Int J Cancer. 2024;154(4):596-606. DOI: 10.1002/ijc.34727