Unit | Clinical Research

Participant in paediatric TB diagnostic trial, Bagamoyo, Tanzania

The Clinical Research Unit (CRU) at Swiss TPH designs, conducts, and reports on clinical research studies, primarily in and for low- and middle-income countries, with a focus on vulnerable populations.

In collaboration with international partner institutions, we conduct high-quality scientific studies in the areas of tuberculosis, HIV/AIDS, febrile illnesses, neglected tropical diseases, non-communicable chronic diseases, and mental health. The goal of our work is to gain knowledge about novel clinical tools or interventions, share our findings with the scientific community and the public, inform health policy, and translate knowledge into improved health. We typically work in multidisciplinary and transdisciplinary projects in which building research capacity plays a central role. We provide teaching, training and mentoring for students and young scientists at Swiss TPH and at our partner organizations around the globe.

 

Klaus Reither

Klaus Reither

, PD Dr. med. et phil.

Beynon F et al. The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms. Glob Health Action. 2024;17:2326253. DOI: 10.1080/16549716.2024.2326253

Bosman S et al. Evaluation of c-reactive protein and computer-aided analysis of chest x-rays as tuberculosis triage tests at health facilities in Lesotho and South Africa. Clin Infect Dis. 2024;79(5):1293-1302. DOI: 10.1093/cid/ciae378

Bresser M et al. Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia. PLoS One. 2024;19(2):e0280105. DOI: 10.1371/journal.pone.0280105

Brown J.A et al. Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial. Lancet Glob Health. 2024;12(8):e1312-e1322. DOI: 10.1016/s2214-109x(24)00183-9

Buziashvili M, Djibuti M, Tukvadze N, DeHovitz J, Baliashvili D. Incidence rate and risk factors for developing active tuberculosis among people living with HIV in Georgia 2019-2020 cohort. Open Forum Infect Dis. 2024;11(9):ofae466. DOI: 10.1093/ofid/ofae466