Unit | Clinical Operations

The Clinical Operations Unit is a specialized contract research organisation (CRO). We plan, conduct and monitor clinical trials in resource-limited settings and on poverty-related diseases like malaria, tuberculosis and human African trypanosomiasis (sleeping sickness). We offer our services to pharmaceutical and biotech companies as well as to academic organisations and NGOs.  

Broad Expertise in Clinical Trials

We are dedicated to the design, implementation, management and monitoring clinical trials (Phase I to Phase IV) on poverty related diseases in resource-constrained countries and settings. We have acquired a significant wealth of experience in conducting often complex clinical trials exposed to a multitude of cultural, scientific and operational challenges. 

Fexinidazole against African Human Trypanosomiasis

Human Africa Trypanosomiasis is a life-threatening neglected disease. To date nifurtimox-eflornithine combined therapy (NECT) is the Standard Treatment for late-stage HAT. Nevertheless, NECT is still far from ideal given the environment in which HAT patients live. There is an urgent need to develop less toxic and easier-to-use products. One promising agent is Fexinidazole.

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Pediatric Praziquantel Formulation for Treating Schistosomiasis

Schistosomes, parasitic blood flukes, cause the chronic disaese schistosomiasis. Today, the gold standard of treatment is praziquantel which is only suitable for adults and school-aged children. Thus, a palliative, effective and safe praziquantel formulation to treat young children is absolutely required. To reach this aim, the Pediatric Praziquantel Consortium was founded in 2012.

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Treatment of Multidrug-Resistant Tuberculosis

Tuberculosis is one of the most deadly infectious diseases in the world. Treatment is complex especially in case of multidrug-resistant tuberculosis. Particularly patients in low-resource countries often lack access or do not complete treatment regimen. TB PRACTECAL is a pioneering new clinical trial aiming to find a radically improved course of treatment for drug-resistant tuberculosis.

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Selected projects at this location: