Modelling for New Schistosomiasis Treatment Thresholds (News)
https://www.swisstph.ch/en/news/news-detail/news/modelling-for-new-schistosomiasis-treatment-thresholds
approaches to fight parasitic worms globally." Centre of expertise in parasitic worm infections Swiss TPH is active in a broad range of activities related to research and control of parasitic worm infections [...] Schistosomiasis is a neglected tropical disease caused by parasitic flatworms. Globally, 250 million people are infected and almost 800 million people are at risk. For high-risk groups, the World Health [...] eggs in the stool and thus may not necessarily detect schistosomiasis when...
Assessment of the factors affecting emergence and spread of artemisinin resistance in Rwanda (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/assessment-of-the-factors-affecting-emergence-and-spread-of-artemisinin-resistance-in-rwanda
impact of malaria control interventions on the spread of artemisinin resistance ยท To monitor ex vivo parasite susceptibility to artemisinin and artemisinin partner drugs Approach and methods: We will carry [...] from DBS and parasitaemia determined by qPCR. Molecular markers of antimalarial drug resistance and parasite population genetic diversity will be characterised by multiplex PCR and next generation sequencing [...] amplicon sequencing. We will collect whole blood from a subset of patients...
<em>Plasmodium</em> gametocytes display homing and vascular transmigration in the host bone marrow (Publications)
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falciparum [...] environment. During the acute phase of infection, we observed vascular leakage resulting in further parasite accumulation in this environment. Mature gametocytes showed high deformability and were found entering
Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides (Publications)
infectious diseases caused by protozoan parasites in tropical and subtropical regions Novel effective safe and inexpensive drugs are required to treat the parasites and contribute to the global goal of
Novel nitro(triazole/imidazole)-based heteroarylamides/ sulfonamides as potential antitrypanosomal agents (Publications)
arylsulfonamides demonstrate significant activity in vitro against Trypanosoma cruzi, the causative parasite of Chagas disease. More importantly, several such analogs displayed significant antichagasic activity [...] against T. cruzi with the most potent generating IC50 values of 1400-fold selectivity toward the parasite. The 2-nitroimidazole-based derivatives were moderately active against T. cruzi and displayed s
Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of <em>Plasmodium falciparum</em> dUTP... (Publications)
of the enzyme can be designed and synthesised with the aim of being developed into novel anti-parasitic drugs. Analogue based design was used to target the Plasmodium falciparum dUTPase (PfdUTPase). The [...] tritylated uracil acetamide derivatives were synthesised and assessed for inhibition of the enzyme and parasite growth in vitro. These compounds were weak inhibitors of the PfdUTPase
Trypanocidal activity of melamine-based nitroheterocycles (Publications)
TbAT1-null mutant parasites, deficient in this transporter, retained sensitivity to these drugs. One compound, a melamine-linked nitrofuran, also showed pronounced activity against parasites in mice. Studies
<em>Plasmodium falciparum</em> genetic diversity in western Kenya highlands (Publications)
prevalence are substantially lower in the highlands than in the lowlands. Despite that the highland parasite populations exhibited reduced number of alleles, lower expected heterozygosity, and infection complexity [...] lowland population, genetic diversity of the highland populations remained high in comparison to parasites from other meso-endemic regions. More than 70% of infections from western Kenya highland study sites
Trypanocidal activity of melamine-based nitroheterocycles (Publications)
TbAT1-null mutant parasites, deficient in this transporter, retained sensitivity to these drugs. One compound, a melamine-linked nitrofuran, also showed pronounced activity against parasites in mice. Studies
<em>Plasmodium falciparum</em> genetic diversity in western Kenya highlands (Publications)
prevalence are substantially lower in the highlands than in the lowlands. Despite that the highland parasite populations exhibited reduced number of alleles, lower expected heterozygosity, and infection complexity [...] lowland population, genetic diversity of the highland populations remained high in comparison to parasites from other meso-endemic regions. More than 70% of infections from western Kenya highland study sites
