Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of <em>Plasmodium falciparum</em> dUTP... (Publications)
of the enzyme can be designed and synthesised with the aim of being developed into novel anti-parasitic drugs. Analogue based design was used to target the Plasmodium falciparum dUTPase (PfdUTPase). The [...] tritylated uracil acetamide derivatives were synthesised and assessed for inhibition of the enzyme and parasite growth in vitro. These compounds were weak inhibitors of the PfdUTPase
Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides (Publications)
infectious diseases caused by protozoan parasites in tropical and subtropical regions Novel effective safe and inexpensive drugs are required to treat the parasites and contribute to the global goal of
<em>Plasmodium</em> gametocytes display homing and vascular transmigration in the host bone marrow (Publications)
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falciparum [...] environment. During the acute phase of infection, we observed vascular leakage resulting in further parasite accumulation in this environment. Mature gametocytes showed high deformability and were found entering
Novel nitro(triazole/imidazole)-based heteroarylamides/ sulfonamides as potential antitrypanosomal agents (Publications)
arylsulfonamides demonstrate significant activity in vitro against Trypanosoma cruzi, the causative parasite of Chagas disease. More importantly, several such analogs displayed significant antichagasic activity [...] against T. cruzi with the most potent generating IC50 values of 1400-fold selectivity toward the parasite. The 2-nitroimidazole-based derivatives were moderately active against T. cruzi and displayed s
Fexinidazole (Page)
https://www.swisstph.ch/en/about/med/clinical-operations/fexinidazole
Trypanosomiasis (HAT) or sleeping sickness is caused by the protozoa Trypanosoma brucei ( T. b .). This parasite is transmitted by the tsetse fly. Two types of trypanosomes are responsible for this potentially [...] b. gambiense and T. b. rhodesiense. HAT is subdivided into two stages. In the early stage, the parasites are located in the blood. This leads to general symptoms like fever, headaches and itching followed [...] by more serious symptoms like anemia, endocrine and kidney dysfunctions....
A multiplex assay for the sensitive detection and quantification of male and female <em>Plasmodium falciparum</em> gametocytes (Publications)
densities at asexual parasite densities above 1000 parasites/microL requires caution to avoid false positive gametocyte signals from spurious transcript levels in ring stage parasites. [...] in either single or multiplex qRT-PCR). FG and MG transcripts were detected in pure ring stage parasites at 10,000- and 100,000-fold reduced frequency for CCp4 and PfMGET, respectively. The CCp4 and PfMGET
The empirical support for the radical cure strategy for eliminating <em>Plasmodium vivax</em> in China (Publications)
We collated data from both published and unpublished malaria parasite inoculation experiments conducted between 1979 and 1988 with parasites from different regions of the People's Republic of China. The [...] (EM) algorithm initialized by hierarchical model-based agglomerative clustering. RESULTS: P. vivax parasites from the seven studies of five southern and central provinces in the People's Republic of China [...] China covering geographies ranging from the south temperate to north...
The empirical support for the radical cure strategy for eliminating <em>Plasmodium vivax</em> in China (Publications)
We collated data from both published and unpublished malaria parasite inoculation experiments conducted between 1979 and 1988 with parasites from different regions of the People's Republic of China. The [...] (EM) algorithm initialized by hierarchical model-based agglomerative clustering. RESULTS: P. vivax parasites from the seven studies of five southern and central provinces in the People's Republic of China [...] China covering geographies ranging from the south temperate to north...
Partially purified <em>Strongyloides ratti</em> antigen improved the diagnostic performance of strongyloidiasis by enzyme-linked immunosorbent assay... (Publications)
subjects with proven strongyloidiasis, Group 2 were subjects with other parasitic infections, and Group 3 were negative parasitic infections. The diagnostic performance and Kappa agreement of the serological [...] and WF-ICT was almost perfect (Kappa = 0.94). The WF antigen reduced cross-reactivity to other parasitic infections, that is, Opisthorchis viverrini, Taenia spp., and hookworms, compared to crude S. ratti [...] the impact of Strongyloides ratti antigen purification using an IgG...
A multiplex assay for the sensitive detection and quantification of male and female <em>Plasmodium falciparum</em> gametocytes (Publications)
densities at asexual parasite densities above 1000 parasites/microL requires caution to avoid false positive gametocyte signals from spurious transcript levels in ring stage parasites. [...] in either single or multiplex qRT-PCR). FG and MG transcripts were detected in pure ring stage parasites at 10,000- and 100,000-fold reduced frequency for CCp4 and PfMGET, respectively. The CCp4 and PfMGET
