Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA (Publications)
c MYB-type domain. Here, we identified the telomere repeat-binding protein PfTRZ in the malaria parasite Plasmodium falciparum, a member of the Alveolate phylum for which TRFs have not been described so
Antimalarial pyrido[1,2-a]benzimidazoles: lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and <em>in... (Publications)
with improved in vivo oral efficacy in the P. berghei mouse model and additional activity against parasite liver and gametocyte stages, making them potential candidates for preclinical development. Inhibition
Sensitive and accurate quantification of human malaria parasites using droplet digital PCR (ddPCR) (Publications)
Accurate quantification of parasite density in the human host is essential for understanding the biology and pathology of malaria. Semi-quantitative molecular methods are widely applied, but the need for [...] for an external standard curve makes it difficult to compare parasite density estimates across studies. Droplet digital PCR (ddPCR) allows direct quantification without the need for a standard curve. ddPCR [...] well as in asymptomatic samples. ddPCR yielded highly reproducible...
Intestinal parasite infections and associated risk factors in communities exposed to wastewater in urban and peri-urban transition zones in Hanoi,... (Publications)
settings, little is known about the extent of intestinal parasite infections. We assessed the point-prevalence and risk factors of intestinal parasite infections in population groups differently exposed to [...] BACKGROUND: Infections with intestinal parasites (helminths and intestinal protozoa) are endemic in Southeast Asia and inappropriate management and reuse of wastewater might exacerbate the risk of human [...] total of 681 individuals had complete data records. Highest point-prevalence...
Effect of praziquantel together with artemether on <em>Schistosoma japonicum </em>parasites of different ages in rabbits (Publications)
The efficacy of combined treatment with praziquantel and artemether against infection with Schistosoma japonicum was tested on infected rabbits, in which 7-to 14-day-old schistosomules and 42-day-old
Co-infection of HIV and parasites in China: <em>Cryptosporidium</em> prevalence in environmental water in HIV/AIDS high endemic areas (Publications)
Cryptosporidium parasite and co-infection of HIV with parasites in HIV/AIDS highly endemic areas in China, in order to understand the waterborne transmission routes of Cryptosporidium parasite in local en
Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites (Publications)
Human schistosomiasis, a chronic and debilitating parasitic disease of the tropics, is ranked second after malaria in terms of public health importance. At present, there is no vaccine available, and [...] artemether; in vivo assessment of drug susceptibility of different developmental stages of schistosome parasites; artemether-induced pathology evidenced by scanning and transmission electron microscopy; the possible
Gastrointestinal parasite egg excretion in young calves in periurban livestock production in Mali (Publications)
To acquire the information needed to improve parasite control in periurban cattle production in Mali, repeated sampling of faeces of 694 calves kept around Bamako was done in 2003/2004. The effects of [...] of season, age, breed, management type, parasite control and presence of sheep on egg and oocyst counts were determined. A Bayesian model was used with a negative binomial distribution and herd and individual [...] , Trichuris sp. and Paramphistomum sp. Season and age effects occurred....
