Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite. AREAS COVERED: Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly
<em>Plasmodium vivax</em> diversity and population structure across four continents (Publications)
Plasmodium vivax is the geographically most widespread human malaria parasite. To analyze patterns of microsatellite diversity and population structure across countries of different transmission intensity [...] Africa, SE-Asia or the South Pacific. Isolates from Uzbekistan were exceptional, as a near-clonal parasite population was observed that was clearly separated from all other populations (FST> 0.2). Outside [...] be taken into account when assessing the impact of control programs on the...
Effects of age, gender and soil-transmitted helminth infection on prevalence of <em>Plasmodium </em>infection among population living in Bata... (Publications)
INTRODUCTION: Malaria and soil-transmitted helminth (STH) co-infection is an important parasitic infection affecting populations in co-endemic countries including Equatorial Guinea. To date, the health [...] other age groups. An amount of 49.3% of the participants infected with T. trichiura had malaria parasites compared with those infected with A. lumbricoides (39.6%) or both (46.8%). CONCLUSIONS: The overlapping [...] involved in the fight against malaria and STH to consider a combined control...
Global diversity and balancing selection of 23 leading <em>Plasmodium falciparum </em>candidate vaccine antigens (Publications)
Investigation of the diversity of malaria parasite antigens can help prioritize and validate them as vaccine candidates and identify the most common variants for inclusion in vaccine formulations. Studies [...] Studies of vaccine candidates of the most virulent human malaria parasite, Plasmodium falciparum, have focused on a handful of well-known antigens, while several others have never been studied. Here we examine [...] vaccine formulations are based on rare haplotypes and thus may have...
Helminth and intestinal protozoa infections, multiparasitism and risk factors in Champasack Province, Lao People's Democratic Republic (Publications)
iary and intestinal parasitic infections and multiparasitism were determined using multiple logistic regressions analyses. PRINCIPAL FINDINGS: MULTIPLE SPECIES INTESTINAL PARASITE INFECTIONS WERE COMMON: [...] COMMON: 86.6% of the study participants harbored at least two and up to seven different parasites concurrently. Regarding nematode infections, hookworm was the most prevalent species (76.8%), followed by Ascaris
Preclinical Research in Infection Biology (Page)
https://www.swisstph.ch/en/research/preclinical-research-in-infection-biology
innovative preclinical research. This research includes the establishment and maintenance of different parasite life cycles and the development and application of in vitro , in vivo and bioanalytical assays. [...] identify one or more antischistosomal drug candidates that are effective against all stages of the parasite and have a novel mechanism of action. To achieve this goal, we will optimise four promising and [...] co-development against both tuberculosis and Buruli ulcer. Involved Units...
Helminth and intestinal protozoa infections, multiparasitism and risk factors in Champasack Province, Lao People's Democratic Republic (Publications)
iary and intestinal parasitic infections and multiparasitism were determined using multiple logistic regressions analyses. PRINCIPAL FINDINGS: MULTIPLE SPECIES INTESTINAL PARASITE INFECTIONS WERE COMMON: [...] COMMON: 86.6% of the study participants harbored at least two and up to seven different parasites concurrently. Regarding nematode infections, hookworm was the most prevalent species (76.8%), followed by Ascaris
Global diversity and balancing selection of 23 leading <em>Plasmodium falciparum </em>candidate vaccine antigens (Publications)
Investigation of the diversity of malaria parasite antigens can help prioritize and validate them as vaccine candidates and identify the most common variants for inclusion in vaccine formulations. Studies [...] Studies of vaccine candidates of the most virulent human malaria parasite, Plasmodium falciparum, have focused on a handful of well-known antigens, while several others have never been studied. Here we examine [...] vaccine formulations are based on rare haplotypes and thus may have...
<em>Plasmodium vivax</em> diversity and population structure across four continents (Publications)
Plasmodium vivax is the geographically most widespread human malaria parasite. To analyze patterns of microsatellite diversity and population structure across countries of different transmission intensity [...] Africa, SE-Asia or the South Pacific. Isolates from Uzbekistan were exceptional, as a near-clonal parasite population was observed that was clearly separated from all other populations (FST> 0.2). Outside [...] be taken into account when assessing the impact of control programs on the...
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite. AREAS COVERED: Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly
