Searched for parasites.

1. Effects of age, gender and soil-transmitted helminth infection on prevalence of <em>Plasmodium </em>infection among population living in Bata... (Publications)

   Effects of age, gender and soil-transmitted helminth infection on prevalence of <em>Plasmodium </em>infection among population living in Bata district, Equatorial Guinea

   Relevance:

   INTRODUCTION: Malaria and soil-transmitted helminth (STH) co-infection is an important parasitic infection affecting populations in co-endemic countries including Equatorial Guinea. To date, the health [...] other age groups. An amount of 49.3% of the participants infected with T. trichiura had malaria parasites compared with those infected with A. lumbricoides (39.6%) or both (46.8%). CONCLUSIONS: The overlapping [...] involved in the fight against malaria and STH to consider a combined control...

2. Validation of the protein kinase <em>Pf</em>CLK3 as a multistage cross-species malarial drug target (Publications)

   Validation of the protein kinase <em>Pf</em>CLK3 as a multistage cross-species malarial drug target

   Relevance:

   target acting at multiple parasite life stages. Consistent with a role for PfCLK3 in RNA splicing, inhibition resulted in the down-regulation of more than 400 essential parasite genes. Inhibition of PfCLK3

3. Biological evaluation and x-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase, an enzyme from the redox... (Publications)

   Biological evaluation and x-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase, an enzyme from the redox metabolism of trypanosoma

   Relevance:

   human African trypanosomiasis, Chagas disease, and the various forms of leishmaniasis are caused by parasites of the family of trypanosomatids. These protozoa possess a unique redox metabolism based on try [...] cruzi TR and in vitro activities (half-maximal inhibitory concentration, IC50 ) against these parasites in the low micromolar range, with high selectivity against human glutathione reductase. X-ray co-crystal

4. Stochastic protein alkylation by antimalarial peroxides (Publications)

   Stochastic protein alkylation by antimalarial peroxides

   Relevance:

   artefenomel undergo reductive cleavage of the pharmacophoric peroxide bond by ferrous heme, released by parasite hemoglobin digestion. The generated carbon-centered radicals alkylate heme in an intramolecular [...] identified in this work and those disclosed in previous studies. Our findings suggest that alkylation of parasite proteins by antimalarial peroxides is likely to be a nonspecific, stochastic process.

5. Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase (Publications)

   Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase

   Relevance:

   The causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on the

6. Structure-activity relationship studies of pyrrolone antimalarial agents (Publications)

   Structure-activity relationship studies of pyrrolone antimalarial agents

   Relevance:

   Plasmodium falciparum K1, a chloroquine- and pyrimethamine-resistant parasite strain, with some derivatives exhibiting good selectivity for parasite over mammalian (L6) cells. Three representative compounds were

7. dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)

   dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors

   Relevance:

   report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase). We have identified a series of triphenylmethane derivatives of [...] group and the side chains of residues Phe46 and Ile117. Immunofluorescence microscopy studies of parasitized red blood cells reveal that enzyme concentrations are highest during the trophozoite/schizont stages

8. FLOTAC for the diagnosis of <em>Hymenolepis spp.</em> infection: proof-of-concept and comparing diagnostic accuracy with other methods (Publications)

   FLOTAC for the diagnosis of <em>Hymenolepis spp.</em> infection: proof-of-concept and comparing diagnostic accuracy with other methods

   Relevance:

   nana is the most common cestode parasitizing humans, yet it is under-diagnosed. We determined the optimal flotation solution (FS) for the diagnosis of this intestinal parasite with the FLOTAC method, and compared

9. Geospatial (s)tools: integration of advanced epidemiological sampling and novel diagnostics (Publications)

   Geospatial (s)tools: integration of advanced epidemiological sampling and novel diagnostics

   Relevance:

   Large-scale control and progressive elimination of a wide variety of parasitic diseases is moving to the fore. Indeed, there is good pace and broad political commitment. Yet, there are some worrying signs [...] d sampling) with innovative diagnostic tools and strategies (e.g. Mini-FLOTAC for detection of parasitic elements and pooling of biological samples) and high-resolution geospatial tools. Recognising these

10. Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds (Publications)

    Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

    Relevance:

    Leishmania donovani axenic parasites while none were deemed active against T. brucei rhodesiense. For the most active/moderately active compounds a moderate selectivity against each parasite was observed. There