<em>In vitro</em> screening of traditional South African malaria remedies against <em>Trypanosoma brucei rhodesiense</em>, <em>Trypanosoma cruzi,... (Publications)
extracts which inhibited the growth of one or more parasites to more than 95 % at 9.7 microg/mL, the IC (50) values against all four protozoal parasites and cytotoxic IC (50)s against rat myoblast L6 cells
Structure-activity relationship studies of pyrrolone antimalarial agents (Publications)
Plasmodium falciparum K1, a chloroquine- and pyrimethamine-resistant parasite strain, with some derivatives exhibiting good selectivity for parasite over mammalian (L6) cells. Three representative compounds were
<em>In vitro</em> screening of traditional South African malaria remedies against <em>Trypanosoma brucei rhodesiense</em>, <em>Trypanosoma cruzi,... (Publications)
extracts which inhibited the growth of one or more parasites to more than 95 % at 9.7 microg/mL, the IC (50) values against all four protozoal parasites and cytotoxic IC (50)s against rat myoblast L6 cells
Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase (Publications)
The causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on the
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase). We have identified a series of triphenylmethane derivatives of [...] group and the side chains of residues Phe46 and Ile117. Immunofluorescence microscopy studies of parasitized red blood cells reveal that enzyme concentrations are highest during the trophozoite/schizont stages
FLOTAC for the diagnosis of <em>Hymenolepis spp.</em> infection: proof-of-concept and comparing diagnostic accuracy with other methods (Publications)
nana is the most common cestode parasitizing humans, yet it is under-diagnosed. We determined the optimal flotation solution (FS) for the diagnosis of this intestinal parasite with the FLOTAC method, and compared
Geospatial (s)tools: integration of advanced epidemiological sampling and novel diagnostics (Publications)
Large-scale control and progressive elimination of a wide variety of parasitic diseases is moving to the fore. Indeed, there is good pace and broad political commitment. Yet, there are some worrying signs [...] d sampling) with innovative diagnostic tools and strategies (e.g. Mini-FLOTAC for detection of parasitic elements and pooling of biological samples) and high-resolution geospatial tools. Recognising these
Biological evaluation and x-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase, an enzyme from the redox... (Publications)
human African trypanosomiasis, Chagas disease, and the various forms of leishmaniasis are caused by parasites of the family of trypanosomatids. These protozoa possess a unique redox metabolism based on try [...] cruzi TR and in vitro activities (half-maximal inhibitory concentration, IC50 ) against these parasites in the low micromolar range, with high selectivity against human glutathione reductase. X-ray co-crystal
Validation of the protein kinase <em>Pf</em>CLK3 as a multistage cross-species malarial drug target (Publications)
target acting at multiple parasite life stages. Consistent with a role for PfCLK3 in RNA splicing, inhibition resulted in the down-regulation of more than 400 essential parasite genes. Inhibition of PfCLK3
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds (Publications)
Leishmania donovani axenic parasites while none were deemed active against T. brucei rhodesiense. For the most active/moderately active compounds a moderate selectivity against each parasite was observed. There
