Stochastic protein alkylation by antimalarial peroxides (Publications)
artefenomel undergo reductive cleavage of the pharmacophoric peroxide bond by ferrous heme, released by parasite hemoglobin digestion. The generated carbon-centered radicals alkylate heme in an intramolecular [...] identified in this work and those disclosed in previous studies. Our findings suggest that alkylation of parasite proteins by antimalarial peroxides is likely to be a nonspecific, stochastic process.
Low quality of routine microscopy for malaria at different levels of the health system in Dar es Salaam (Publications)
98.7%, respectively. Median parasitaemia was only three parasites per 200 white blood cells (WBC) by routine microscopy compared to 1226 parasites per 200 WBC by expert microscopy. Before RDT implementation [...] facilities: 71% before versus 72% after. Two cross-sectional health facility surveys confirmed that the parasite rate in febrile patients was low in Dar es Salaam during both the rainy season (13.6%) and the dry [...] Over-diagnosis was massive, with many false positive results reported...
Ultrastructural comparison of the midgut epithelia of fleas with different feeding behavior patterns (<em>Xenopsylla cheopis</em>, <em>Echidnophaga... (Publications)
species, including temporary parasitic fleas (both sexes of Xenopsylla cheopis, males and immature females of Echidnophaga gallinacea and Tunga penetrans) and stationary parasitic fleas (mature females of [...] synthesis of digestive enzymes. (3) More conspicious changes occur in the midgut of the stationary parasitic and maturing females of E. gallinacea and T. penetrans. The nuclear volumes of the digestive cells [...] been demonstrated that the structure of the midgut epithelium is influenced...
Low quality of routine microscopy for malaria at different levels of the health system in Dar es Salaam (Publications)
98.7%, respectively. Median parasitaemia was only three parasites per 200 white blood cells (WBC) by routine microscopy compared to 1226 parasites per 200 WBC by expert microscopy. Before RDT implementation [...] facilities: 71% before versus 72% after. Two cross-sectional health facility surveys confirmed that the parasite rate in febrile patients was low in Dar es Salaam during both the rainy season (13.6%) and the dry [...] Over-diagnosis was massive, with many false positive results reported...
Ultrastructural comparison of the midgut epithelia of fleas with different feeding behavior patterns (<em>Xenopsylla cheopis</em>, <em>Echidnophaga... (Publications)
species, including temporary parasitic fleas (both sexes of Xenopsylla cheopis, males and immature females of Echidnophaga gallinacea and Tunga penetrans) and stationary parasitic fleas (mature females of [...] synthesis of digestive enzymes. (3) More conspicious changes occur in the midgut of the stationary parasitic and maturing females of E. gallinacea and T. penetrans. The nuclear volumes of the digestive cells [...] been demonstrated that the structure of the midgut epithelium is influenced...
Interventions for Schistosomiasis Elimination in Zanzibar (News)
https://www.swisstph.ch/en/news/news-detail/news/interventions-for-schistosomiasis-elimination-in-zanzibar
advanced. Swiss TPH: A centre of expertise in parasitic worm infections Swiss TPH is active in a broad range of activities related to research and control of parasitic worm infections. The work comprises basic [...] Schistosomiasis is a neglected tropical disease caused by blood flukes (parasitic flatworms). Infection occurs when individuals, particularly children, are exposed to contaminated natural freshwater while [...] additional interventions - such as snail control and behaviour change -...
Plasmodium vivax Transmission Model (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/plasmodium-vivax-transmission-model
for Plasmodium vivax transmission to support decision-making and advocacy in countries where this parasite is dominant. This compartmental model accounts specifically for the liver stages of P. vivax malaria [...] recently been refined to include imported infections as well as treatment of blood and/or liver stages parasites. Additional ongoing development of the model include the account for delay in treatment, the inclusion
Structure–activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of<em> Haemonchus contortus</em> development (Publications)
tolfenpyrad (TFP), unexpectedly and potently inhibits the development of L4 larval stages of the parasitic nematode Haemonchus contortus with an IC50 value of 0.03 microM while displaying good selectivity [...] Selected compounds from the series also showed promising activity against a panel of other different parasitic nematodes such as hookworms and whipworms.
The effect of temperature on the development of <em>Angiostrongylus cantonensis</em> (Chen 1935) in <em>Pomacea canaliculata</em> (Lamarck 1822) (Publications)
Angiostrongyliasis cantonensis, clinically presented as eosinophilic meningitis, is a snail-borne parasitic disease. We studied the effects of different temperatures on the larval development of Angiostrongylus [...] thermal constant was 262.53 degree-days. These parameters could be helpful in estimating the number of parasite generations in a year and the impact of climate change on the distribution of A. cantonensis
Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models (Publications)
been relatively little progress towards identifying orally available chemotypes active against the parasite in vivo. Here, we report the lead optimization of a purine-nitrile scaffold that inhibits the essential [...] inhibitor that had potent activity against the trypanosomal protease TbcatB in vitro and cultured parasites ex vivo was optimized by rationally driven medicinal chemistry to an inhibitor that is orally available
