Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay (Publications)
BACKGROUND: Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile of [...] I(R539T). CONCLUSION: If the in vitro RSA does indeed predict the potency of compounds against parasites with increased tolerance to artemisinin and its derivatives, then the herein presented data suggest
Inhibition of <em>Plasmodium falciparum</em> Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles (Publications)
Malaria caused by the protozoan parasite Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world. One molecular target that should receive more attention is the [...] chaperone Hsp90. It is essential and highly conserved in all eukaryotes, including in protozoan parasites. We have identified an amino-alcohol carbazole (N-CBZ) as a PfHsp90-selective inhibitor by virtually
1,2-substituted 4-(1H)-quinolones: synthesis, antimalarial and antitrypanosomal activities in vitro (Publications)
cytotoxicity against L-6 cells in vitro. Furthermore, selectivity indices were also determined for both parasites. All compounds tested showed antimalarial activity at low micromolar concentrations, with varied [...] active against P. falciparum, with an IC50 value of 90 nM and good selectivity for the malarial parasite compared to the L-6 cells. Compound 10a, on the other hand, showed a strong antitrypanosomal effect
A <em>Plasmodium </em>membrane receptor platform integrates cues for egress and invasion in blood forms and activation of transmission stages (Publications)
Critical events in the life cycle of malaria-causing parasites depend on cyclic guanosine monophosphate homeostasis by guanylyl cyclases (GCs) and phosphodiesterases, including merozoite egress or invasion [...] membrane receptor platform that senses signals triggering processes specific to an intracellular parasitic lifestyle, including host cell egress and invasion to ensure intraerythrocytic amplification and
I remember you :Lung epithelial cells memory in Hookworm infection (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/i-remember-you-lung-epithelial-cells-memory-in-hookworm-infection
damage to their host. One of this most striking damage happens in the lungs during migration of parasites such as Hookworms or Ascaris. Short-term this results in pulmonary hemorrhage, while long-term pulmonary [...] remodeling is associated with poor lung function and recently infection with a lung-migrating helminth parasite has been shown to increase the risk of asthma development. Despite recent evidences that helminth
Drug Discovery Work (Page)
https://www.swisstph.ch/en/about/mpi/parasite-chemotherapy/drug-discovery-work
Drug Discovery Work Tropical parasitic diseases, as malaria, African sleeping sickness, Chagas disease or Leishmaniasis represent still a large health risk for a majority of the worlds population. These [...] leading centre for WHO/TDR for in vitro and in vivo drug screening against human infectious protozoan parasites. Within this screening mandate we have more then 20 collaborations worldwide. These screening activities [...] activities complement activities within the European COST B22 action...
Schistosomes, snails and climate change: current trends and future expectations (Publications)
mainly in tropical and subtropical countries, is currently unknown, but likely to vary with the snail-parasite species' specific ecologies and the spatio-temporal scale of investigation. Here, by means of a [...] associated with climate change responses were found to be variable across geographical regions and snail-parasite taxonomic groups. Indeed, the strongest evidence stems from the People's Republic of China pertaining [...] temperatures. The consequences for schistosomiasis...
Very high carriage of gametocytes in asymptomatic low-density <em>Plasmodium falciparum</em> and <em>P. vivax</em> infections in western Thailand (Publications)
pfs25 transcripts was strongly dependent on parasite density. pvs25 transcript numbers, a measure of gametocyte density, were also highly correlated with parasite density (r 2 = 0.82, P < 0.001). CONCLUSIONS: [...] Kanchanaburi and Ratchaburi provinces of Thailand in 2012. The presence of P. falciparum and P. vivax parasites was determined using 18S rRNA qPCR. Gametocytes were also detected by pfs25 / pvs25 qRT-PCRs. RESULTS:
Toxocariasis-associated cardiac diseases: a systematic review of the literature (Publications)
Toxocariasis, caused by Toxocara canis or Toxocara catis, is a worldwide occurring parasitic disease, reaching high prevalences especially in tropical and subtropical countries. The clinical presentation [...] histological analysis was performed (either pre- or post-mortem), granulomas or remnants of the parasite were detected. In the other six cases, findings were non-specific; the damage of the heart was equally [...] corticosteroid appears to be a valuable option. For the daily clinical work,...
Global burden of human food-borne trematodiasis: a systematic review and meta-analysis (Publications)
trematodiases are a group of neglected tropical diseases caused by liver, lung, and intestinal parasitic fluke infections. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD [...] 1980, and Dec 31, 2008. We used a broad search strategy with a combination of search terms and parasite and disease names. The initial search results were then screened on the basis of title, abstract [...] epidemiological disease parameters and methodological features for estimating the...
