Malaria vaccine candidate: design of a multivalent subunit alpha-helical coiled coil poly-epitope (Publications)
together via a non-immunogenic linker. Only peptides that are targets of human antibodies with anti-parasite in vitro biological activitieswere incorporated. One of the constructs, P181, was well recognized [...] s in both immunofluorescence and western blot assays. In addition, specific antibodiesinhibited parasite development in anantibody dependent cellular inhibition (ADCI) assay. Naturally induced antigen-specific
A role for apical membrane antigen 1 during invasion of hepatocytes by <em>Plasmodium falciparum</em> sporozoites (Publications)
invade hepatocytes, as a first and obligatory step of the parasite life cycle in man. Hepatocyte invasion involves proteins secreted from parasite vesicles called micronemes, the most characterized being
Antimalarial efficacy of MMV390048, an inhibitor of <em>Plasmodium</em> phosphatidylinositol 4-kinase (Publications)
kinase of the Plasmodium parasite, phosphatidylinositol 4-kinase, as the molecular target of MMV390048. The ability of MMV390048 to block all life cycle stages of the malaria parasite suggests that this compound
Cherchez l'electron (Publications)
also defective in DNA repair further indicate whether the resultant metabolites interfere with the parasite's genome. This set of T. brucei indicator lines provides a tool for the deconvolution of the mechanisms [...] activation and drug action that will facilitate the rational development of bioreductive prodrugs for parasite chemotherapy. This article is protected by copyright. All rights reserved.
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
The reliance on one drug, praziquantel, to treat the parasitic disease schistosomiasis in millions of people a year shows the need to further develop a pipeline of new drugs to treat this disease. Recently [...] d compounds containing quinoxaline moieties were first assayed against the larval stage of this parasite, newly transformed schistosomula (NTS); of these, 16 killed over 70% NTS at 10 muM. Further testing
In vitro antiprotozoal activity of extracts of five Turkish Lamiaceae species (Publications)
Nepeta nuda subsp. nuda and Marrubium astracanicum subsp. macrodon) were evaluated against four parasitic protozoa, i.e. Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum [...] reference drugs. All crude MeOH extracts showed antiprotozoal potential against at least three parasites, so they were dispersed in water and partitioned against n-hexane and chloroform to yield three
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
The reliance on one drug, praziquantel, to treat the parasitic disease schistosomiasis in millions of people a year shows the need to further develop a pipeline of new drugs to treat this disease. Recently [...] d compounds containing quinoxaline moieties were first assayed against the larval stage of this parasite, newly transformed schistosomula (NTS); of these, 16 killed over 70% NTS at 10 muM. Further testing
In vitro antiprotozoal activity of extracts of five Turkish Lamiaceae species (Publications)
Nepeta nuda subsp. nuda and Marrubium astracanicum subsp. macrodon) were evaluated against four parasitic protozoa, i.e. Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum [...] reference drugs. All crude MeOH extracts showed antiprotozoal potential against at least three parasites, so they were dispersed in water and partitioned against n-hexane and chloroform to yield three
A role for apical membrane antigen 1 during invasion of hepatocytes by <em>Plasmodium falciparum</em> sporozoites (Publications)
invade hepatocytes, as a first and obligatory step of the parasite life cycle in man. Hepatocyte invasion involves proteins secreted from parasite vesicles called micronemes, the most characterized being
Malaria vaccine candidate: design of a multivalent subunit alpha-helical coiled coil poly-epitope (Publications)
together via a non-immunogenic linker. Only peptides that are targets of human antibodies with anti-parasite in vitro biological activitieswere incorporated. One of the constructs, P181, was well recognized [...] s in both immunofluorescence and western blot assays. In addition, specific antibodiesinhibited parasite development in anantibody dependent cellular inhibition (ADCI) assay. Naturally induced antigen-specific
