Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries (Publications)
are parasitic protozoa which cause a spectrum of diseases, including trypanosomiasis and leishmaniasis, affecting millions of humans and animals worldwide. The surface of most protozoan parasites is heavily
Transporters of <em>Trypanosoma brucei</em>: phylogeny, physiology, pharmacology (Publications)
sickness, T. b. gambiense and T. b. rhodesiense, as well as the livestock-pathogenic T. b. brucei. The parasites are transmitted by the tsetse fly and occur exclusively in sub-Saharan Africa. T. brucei are not [...] transport proteins of T. brucei, their contribution to homeostasis and metabolism in the context of a parasitic lifestyle, and their pharmacological role as potential drug targets or routes of drug entry. Tr
Addressing the intracellular vestibule of the plasmodial lactate transporter PfFNT by p-substituted inhibitors amplifies <em>in vitro</em> activity (Publications)
Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as substrate analogs with [...] p-amine substitutions were rapidly metabolized, the more stable p-acetanilide cleared 99.7% of parasites at 4 × 50 mg kg(-1) in a mouse malaria model. Future stabilization of the p-substitution against
Antimalarial efficacy of MMV390048, an inhibitor of <em>Plasmodium</em> phosphatidylinositol 4-kinase (Publications)
kinase of the Plasmodium parasite, phosphatidylinositol 4-kinase, as the molecular target of MMV390048. The ability of MMV390048 to block all life cycle stages of the malaria parasite suggests that this compound
Cherchez l'electron (Publications)
also defective in DNA repair further indicate whether the resultant metabolites interfere with the parasite's genome. This set of T. brucei indicator lines provides a tool for the deconvolution of the mechanisms [...] activation and drug action that will facilitate the rational development of bioreductive prodrugs for parasite chemotherapy. This article is protected by copyright. All rights reserved.
Feasibility and Economic Evaluation of Improved Child Deworming (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/feasibility-and-economic-evaluation-of-improved-child-deworming
Parasitic worm infections are still very common, particularly among children living in areas with limited access to safe drinking water and adequate sanitation. Additionally, this age group is at highest [...] a large proportion of the treated children, since common drugs show low cure rates against some parasitic worm species or are not suitable for administration to young children. This project aims at promoting
Malaria | Swiss TPH (Page)
https://www.swisstph.ch/en/topics/malaria
disease caused by Plasmodium parasites. The parasites are spread to people through the bites of infected female Anopheles mosquitoes, called malaria vectors. There are five parasite species that cause malaria [...] fields. We conduct basic research on the biology of Plasmodium spp. , including gene regulation and parasite-host interactions. We identify and test new diagnostics, drugs, immunotherapies and vaccines for [...] Show More Key Facts About Malaria Malaria is a Major Disease Burden...
Population genetic structure and hybridization of schistosomes in schoolchildren in Côte d’Ivoire (Publications)
gy and provide better insight into parasite gene flow. Objectives: This Ph.D. thesis had two major aims. The first was to expand our understanding of the parasite’s transmission dynamics to update epi [...] the effect of treatment on parasite population genetics in Côte d’Ivoire. New research is needed on population genetics in human and animal schistosomes to evaluate the parasite’s gene flow. [...] Background: Schistosomiasis is a water-based chronic parasitic disease caused by trematode worms...
Population genetic structure and hybridization of schistosomes in schoolchildren in Côte d’Ivoire (Publications)
gy and provide better insight into parasite gene flow. Objectives: This Ph.D. thesis had two major aims. The first was to expand our understanding of the parasite’s transmission dynamics to update epi [...] the effect of treatment on parasite population genetics in Côte d’Ivoire. New research is needed on population genetics in human and animal schistosomes to evaluate the parasite’s gene flow. [...] Background: Schistosomiasis is a water-based chronic parasitic disease caused by trematode worms...
Socially marketed insecticide-treated nets improve malaria and anaemia in pregnancy in southern Tanzania (Publications)
2-41). Multiparous ITN users had a twofold decrease in parasite density compared with multiparous non-ITN users (625 parasites/microl vs. 1173 parasited/microl: P=0.01). Fewer ITN users were anaemic (Hb <
