Characterising co-infections with <em>Plasmodium </em>spp., <em>Mansonella perstans</em> or <em>Loa loa </em>in asymptomatic children, adults and... (Publications)
with malaria in an asymptomatic population. METHODOLOGY: M. perstans, L. loa and Plasmodium spp. parasites were monitored by qPCR in a cross-sectional study using DNA extracted from a subset malaria rapid [...] infection were more prominent in male (10.5%) compared to female (3.9%) survey participants. M. perstans parasite density and positivity rate was higher among older people and the population living in rural areas [...] M. perstans infected, respectively. No increased risk of being...
High-resolution genotyping and mapping of recombination and gene conversion in the protozoan <em>Theileria parva</em> using whole genome sequencing (Publications)
Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle [...] clones derived from ticks fed on cattle that had been simultaneously co-infected with two different parasite isolates. RESULTS: By comparing the genome sequences, we were able to genotype over 64 thousand
<em>Plasmodium falciparum</em> resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular... (Publications)
monitoring of parasite resistance has become an important complementary tool in establishing rational anti-malarial drug policies. Community surveys provide a representative sample of the parasite population [...] similar in clinical and community samples from the same site. CONCLUSIONS: The relationship between parasite genetics and in vivo treatment failure rate is not straightforward. The frequencies of genetic
Phylogeography and taxonomy of <em>Trypanosoma brucei</em> (Publications)
BACKGROUND: Characterizing the evolutionary relationships and population structure of parasites can provide important insights into the epidemiology of human disease. METHODOLOGY/PRINCIPAL FINDINGS: We [...] sickness) in sub-Saharan Africa, and to examine the relationship between Tbr and the non-human infective parasite T. b. brucei (Tbb) in eastern and southern Africa. A Bayesian phylogeny and haplotype network based [...] Tbg group 1. Limited diversity combined with a wide geographical...
Characterising co-infections with <em>Plasmodium </em>spp., <em>Mansonella perstans</em> or <em>Loa loa </em>in asymptomatic children, adults and... (Publications)
with malaria in an asymptomatic population. METHODOLOGY: M. perstans, L. loa and Plasmodium spp. parasites were monitored by qPCR in a cross-sectional study using DNA extracted from a subset malaria rapid [...] infection were more prominent in male (10.5%) compared to female (3.9%) survey participants. M. perstans parasite density and positivity rate was higher among older people and the population living in rural areas [...] M. perstans infected, respectively. No increased risk of being...
<em>Plasmodium falciparum</em> resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular... (Publications)
monitoring of parasite resistance has become an important complementary tool in establishing rational anti-malarial drug policies. Community surveys provide a representative sample of the parasite population [...] similar in clinical and community samples from the same site. CONCLUSIONS: The relationship between parasite genetics and in vivo treatment failure rate is not straightforward. The frequencies of genetic
High-resolution genotyping and mapping of recombination and gene conversion in the protozoan <em>Theileria parva</em> using whole genome sequencing (Publications)
Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle [...] clones derived from ticks fed on cattle that had been simultaneously co-infected with two different parasite isolates. RESULTS: By comparing the genome sequences, we were able to genotype over 64 thousand
Phylogeography and taxonomy of <em>Trypanosoma brucei</em> (Publications)
BACKGROUND: Characterizing the evolutionary relationships and population structure of parasites can provide important insights into the epidemiology of human disease. METHODOLOGY/PRINCIPAL FINDINGS: We [...] sickness) in sub-Saharan Africa, and to examine the relationship between Tbr and the non-human infective parasite T. b. brucei (Tbb) in eastern and southern Africa. A Bayesian phylogeny and haplotype network based [...] Tbg group 1. Limited diversity combined with a wide geographical...
Socially marketed insecticide-treated nets improve malaria and anaemia in pregnancy in southern Tanzania (Publications)
2-41). Multiparous ITN users had a twofold decrease in parasite density compared with multiparous non-ITN users (625 parasites/microl vs. 1173 parasited/microl: P=0.01). Fewer ITN users were anaemic (Hb <
Characterization of the interaction network of exported proteins in Plasmodium falciparum (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/characterization-of-the-interaction-network-of-exported-proteins-in-plasmodium-falciparum
of virulence factors to the surface of infected host cells and other modifications allowing the parasite’s survival in its host cell which are the sole cause of morbidity and mortality. P. falciparum, the [...] presentation of adhesins on the surface or change of membrane rigidity and permeability. Why the parasites need to export such large number of proteins is unknown and their interaction is not understood [...] falciparum make this project more feasible. Using the CRISPR/CAS9 system we will...
