Searched for parasites.

1. MalCommit - Understanding Sexual Commitment and Early Differentiation of Malaria Transmission Stages (Projects)

   MalCommit - Understanding Sexual Commitment and Early Differentiation of Malaria Transmission Stages

   Relevance:
   https://www.swisstph.ch/en/projects/project-detail/project/malcommit-understanding-sexual-commitment-and-early-differentiation-of-malaria-transmission-stages

   to understand the processes responsible for the differentiation of asexual malaria blood stage parasites into sexual forms. The anticipated results may open up new avenues for the development of trans

2. Performance of antigen concentration thresholds for attributing fever to malaria among outpatients in Angola (Publications)

   Performance of antigen concentration thresholds for attributing fever to malaria among outpatients in Angola

   Relevance:

   The density of malaria parasites is a key determinant in whether or not an infected individual develops fever. While the pyrogenic threshold for malaria parasite density has been well-studied, there is

3. The complex relationship of exposure to new <em>Plasmodium</em> infections and incidence of clinical malaria in Papua New Guinea (Publications)

   The complex relationship of exposure to new <em>Plasmodium</em> infections and incidence of clinical malaria in Papua New Guinea

   Relevance:

   transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax [...] Pv (IR=0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the

4. Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests (Publications)

   Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests

   Relevance:

   blood retained on the RDTs allows detection and quantification of P. falciparum parasites from asymptomatic patients with parasite densities as low as 1 Pf/μL blood using reverse transcription quantitative

5. Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation (Publications)

   Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation

   Relevance:

   concerns about drug resistance. New therapeutic alternatives targeting critical pathways within the parasite are therefore urgently needed. Hemozoin formation in Schistosoma presents one such target. We assessed [...] observed between beta-hematin inhibitory and antischistosomal activities against both larval and adult parasites, suggesting possible presence of other target(s) or a mode of inhibition of crystal formation that

6. <em>Trypanosoma brucei</em> eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids (Publications)

   <em>Trypanosoma brucei</em> eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids

   Relevance:

   Amino acid transporters are crucial for parasite survival since the cellular metabolism of parasitic protozoa depends on the up-take of exogenous amino acids. Amino acid transporters are also of high

7. Towards a comprehensive simulation model of malaria epidemiology and control (Publications)

   Towards a comprehensive simulation model of malaria epidemiology and control

   Relevance:

   stochastic series of parasite densities, and naturally acquired immunity acts by reducing densities. Morbidity and mortality risks, and infectiousness to vectors, depend on parasite densities. The simulated

8. Spatial distribution of <em>Biomphalaria</em> spp., the intermediate host snails of <em>Schistosoma mansoni</em> in Brazil (Publications)

   Spatial distribution of <em>Biomphalaria</em> spp., the intermediate host snails of <em>Schistosoma mansoni</em> in Brazil

   Relevance:

   Schistosomiasis mansoni remains an important parasitic disease of man, endemic in large parts of sub-Saharan Africa, the Middle East, South America and the Caribbean. The aetiological agent is the trematode [...] Schistosoma mansoni, whereas aquatic snails of the genus Biomphalaria act as intermediate hosts in the parasite life cycle. In Brazil, the distribution of Biomphalaria spp. is closely associated with the occurrence

9. Placental infection with <em>Plasmodium vivax</em>: a histopathological and molecular study (Publications)

   Placental infection with <em>Plasmodium vivax</em>: a histopathological and molecular study

   Relevance:

   negative in peripheral blood. By histology, three placentas with P. vivax mono-infection showed parasitized erythrocytes in the intervillous space but no hemozoin in macrophages nor increased intervillous [...] us inflammatory cells. In contrast, seven placentas positive for P. falciparum presented parasites and hemozoin in macrophages or fibrin as well as intervillous inflammatory infiltrates.Conclusions. P

10. Search for antiprotozoal activity in herbal medicinal preparations; new natural leads against neglected tropical diseases (Publications)

    Search for antiprotozoal activity in herbal medicinal preparations; new natural leads against neglected tropical diseases

    Relevance:

    Chagas disease, Leishmaniasis, and Malaria are infectious diseases caused by unicellular eukaryotic parasites ("protozoans"). The three first mentioned are classified as Neglected Tropical Diseases (NTDs) by [...] extracts from 53 HMPs on the German market were tested by a Multiple-Target-Screening (MTS) against parasites of the genera Leishmania, Trypanosoma, and Plasmodium. Sixteen HMPs showed in vitro activity against