Searched for parasites.

1. The complex relationship of exposure to new <em>Plasmodium</em> infections and incidence of clinical malaria in Papua New Guinea (Publications)

   The complex relationship of exposure to new <em>Plasmodium</em> infections and incidence of clinical malaria in Papua New Guinea

   Relevance:

   transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax [...] Pv (IR=0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the

2. Spatial distribution of <em>Biomphalaria</em> spp., the intermediate host snails of <em>Schistosoma mansoni</em> in Brazil (Publications)

   Spatial distribution of <em>Biomphalaria</em> spp., the intermediate host snails of <em>Schistosoma mansoni</em> in Brazil

   Relevance:

   Schistosomiasis mansoni remains an important parasitic disease of man, endemic in large parts of sub-Saharan Africa, the Middle East, South America and the Caribbean. The aetiological agent is the trematode [...] Schistosoma mansoni, whereas aquatic snails of the genus Biomphalaria act as intermediate hosts in the parasite life cycle. In Brazil, the distribution of Biomphalaria spp. is closely associated with the occurrence

3. Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga <em>Bifurcaria bifurcata</em> (Publications)

   Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga <em>Bifurcaria bifurcata</em>

   Relevance:

   constants. Bifurcatriol (1) was tested for in vitro antiprotozoal activity towards a small panel of parasites (Plasmodium falciparum, Trypanosoma brucei rhodesiense, T. cruzi, and Leishmania donovani) and [...] cytotoxicity against mammalian primary cells. The highest activity was exerted against the malaria parasite P. falciparum (IC50 value 0.65 mug/mL) with low cytotoxicity (IC50 value 56.6 mug/mL). To our knowledge

4. Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests (Publications)

   Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests

   Relevance:

   blood retained on the RDTs allows detection and quantification of P. falciparum parasites from asymptomatic patients with parasite densities as low as 1 Pf/μL blood using reverse transcription quantitative

5. <em>Trypanosoma brucei</em> eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids (Publications)

   <em>Trypanosoma brucei</em> eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids

   Relevance:

   Amino acid transporters are crucial for parasite survival since the cellular metabolism of parasitic protozoa depends on the up-take of exogenous amino acids. Amino acid transporters are also of high

6. Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation (Publications)

   Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation

   Relevance:

   concerns about drug resistance. New therapeutic alternatives targeting critical pathways within the parasite are therefore urgently needed. Hemozoin formation in Schistosoma presents one such target. We assessed [...] observed between beta-hematin inhibitory and antischistosomal activities against both larval and adult parasites, suggesting possible presence of other target(s) or a mode of inhibition of crystal formation that

7. Performance of antigen concentration thresholds for attributing fever to malaria among outpatients in Angola (Publications)

   Performance of antigen concentration thresholds for attributing fever to malaria among outpatients in Angola

   Relevance:

   The density of malaria parasites is a key determinant in whether or not an infected individual develops fever. While the pyrogenic threshold for malaria parasite density has been well-studied, there is

8. Drug repurposing in the chemotherapy of infectious diseases (Publications)

   Drug repurposing in the chemotherapy of infectious diseases

   Relevance:

   targets in the apicoplast of malaria parasites), whereas those that are convergent arise from a shared lifestyle (e.g., the susceptibility of bacteria, parasites, and tumor cells to antifolates due to

9. Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the <em>Plasmodium</em> life cycle (Publications)

   Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the <em>Plasmodium</em> life cycle

   Relevance:

   bond. Ru(II) - and Au(I) -AQ complexes were demonstrated to be potent and efficacious in inhibiting parasite growth in multiple stages of the Plasmodium life cycle as assayed in vitro and in vivo. These properties [...] the suppression of heme detoxification induced by AQ, while also inhibiting other processes in the parasite life cycle; this can be attributed to the action of the metallic species. Altogether, these findings

10. Pascal Mäser Appointed Full Professor at the University of Basel (News)

    Pascal Mäser Appointed Full Professor at the University of Basel

    Relevance:
    https://www.swisstph.ch/en/news/news-detail/news/pascal-maeser-appointed-full-professor-at-the-university-of-basel

    leads the Parasite Chemotherapy Unit at the Department of Medical Parasitology and Infection Biology (MPI) at Swiss TPH. Mäser’s research focuses on drug discovery for trypanosomatid parasites and malaria