Early assessment of antibodies decline in Chagas patients following treatment using a serological multiplex immunoassay (Publications)
becoming more global due to the migration of infected individuals. The currently available anti-parasitic drugs, nifurtimox and benznidazole, remain insufficiently evaluated for their efficacy in adult [...] (MultiCruzi), combined with advanced statistical analytical methods, to measure the response to anti-parasitic treatment of adult Chagas patients. Applying this approach to serum samples from adult patients
Polyamidoamine nanoparticles for the oral administration of antimalarial drugs (Publications)
for future interventions stress the importance of also targeting the transmission stages of the parasite as it passes between humans and mosquitoes. Orally administered polyamidoamine (PAA) nanoparticles [...] blood cells. The weak antimalarial activity of some PAAs was found to operate through inhibition of parasite invasion, whereas the observed polymer intake by macrophages indicated a potential of PAAs for the
CRISPR-Cas9-modified <em>pfmdr1</em> protects <em>Plasmodium falciparum </em>asexual blood stages and gametocytes against a class of... (Publications)
transmissible gametocyte forms. Genome sequence analyses of in vitro-derived ACT-451840-resistant parasites revealed single nucleotide polymorphisms in pfmdr1, which encodes a digestive vacuole membrane-bound [...] based gene editing confirmed that PfMDR1 point mutations mediated ACT-451840 resistance. Resistant parasites demonstrated increased susceptibility to the clinical drugs lumefantrine, mefloquine, quinine and
Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency (Publications)
eukaryotic parasites. Building on the genome-wide localisation screen in Trypanosoma brucei we identify conserved proteins with an analogous asymmetric localisation in the related parasite Leishmania mexicana
Impedance-based microfluidic assay for automated antischistosomal drug screening (Publications)
Schistosomiasis is a neglected tropical disease, caused by parasitic worms, which affects almost 200 million people worldwide. For over 40 years, chemotherapeutic treatment has relied on the administration [...] of electrodes and a channel of variable geometry to enable counting and size detection of single parasite larvae and the collective evaluation of the motility of the larvae as an unbiased estimator for
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
anti-malarial activity by phenotypic screening. Selection of SW042-resistant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed [...] purification was facilitated by His(8)-tag introduction onto β7. Inhibition of Pfβ5 correlated with parasite killing, without inhibiting human proteasome isoforms or showing cytotoxicity. The Pf_proteasome_SW584
Chemoproteomics validates selective targeting of <em>Plasmodium</em> M1 alanyl aminopeptidase as an antimalarial strategy (Publications)
methods based on thermal stability and limited proteolysis of whole parasite lysates revealed that MIPS2673 solely targets PfA-M1 in parasites, with limited proteolysis also enabling estimation of the binding
Medical Parasitology and Infection Biology | Departments of Swiss TPH (Page)
https://www.swisstph.ch/en/about/mpi
News 30.06.2023 New Compounds Show Promise in Transforming Treatment of Parasitic Diseases 17.05.2023 New Treatment for Human Parasitic Worm Infections Shows High Efficacy 27.04.2023 Time to Deliver Zero Malaria: [...] Immunology Gene Regulation Helminth Drug Development Helminth Immunology Malaria Host Interactions Parasite Chemotherapy Unit Tuberculosis Ecology and Evolution Unit Tuberculosis Immunology Viral Immunology [...] Immunology Gene Regulation Helminth Drug Development Helminth...
Fexinidazole: a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness (Publications)
the anti-parasitic properties and the pharmacokinetic, metabolic and toxicological profile of fexinidazole have been assessed. METHODS AND FINDINGS: Standard in vitro and in vivo anti-parasitic activity [...] BACKGROUND: Human African trypanosomiasis (HAT), also known as sleeping sickness, is a fatal parasitic disease caused by trypanosomes. Current treatment options for HAT are scarce, toxic, no longer effective [...] infection respectively, the latter being a model for the advanced and fatal...
Fexinidazole: a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness (Publications)
the anti-parasitic properties and the pharmacokinetic, metabolic and toxicological profile of fexinidazole have been assessed. METHODS AND FINDINGS: Standard in vitro and in vivo anti-parasitic activity [...] BACKGROUND: Human African trypanosomiasis (HAT), also known as sleeping sickness, is a fatal parasitic disease caused by trypanosomes. Current treatment options for HAT are scarce, toxic, no longer effective [...] infection respectively, the latter being a model for the advanced and fatal...
