Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: antimicrobial evaluation and mechanistic insights (Publications)
against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum. All compounds were active against the two strains, generally showing enhanced [...] revealed that the hybrids were relatively non-cytotoxic and demonstrated selective killing of the parasite. Based on favourable in vitro antiplasmodial and cytotoxicity data, the most active phenyl (4c)
Ectoparasites of endemic and domestic animals in southwest Madagascar (Publications)
15 host species. There was no indication for seasonal or habitat effects on parasite infection. A large portion of the parasites was host-specific. Some ectoparasite species were shared either by several
A blind passenger: a rare case of documented seroconversion in an <em>Angiostrongylus cantonensis</em> induced eosinophilic meningitis in a traveler... (Publications)
consumption of raw or undercooked paratenic or intermediate hosts, is the most common cause of parasitic eosinophilic meningitis worldwide. While the majority of A. cantonensis cases are reported from [...] symptoms. Repeated serology confirmed seroconversion 2 weeks after treatment initiation. Discussion: Parasitic etiology must be considered in returning travelers who present with symptoms compatible with a central
Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: <em>in vivo</em> studies (Publications)
Background: Chagas disease is caused by the parasite Trypanosoma cruzi, is endemic in Latin America and leads to an estimated 14,000 deaths per year and around 100 million people at risk of infection. [...] compounds of different chemical classes were included. A fast luminescence assay with transgenic parasites that express luciferase, and live imaging techniques were used. A total of 11 out of 13 compounds
<em>Trypanosoma brucei brucei</em>: a model for cerebral trypanosomiasis in mice--an immunological, histological and electronmicroscopic study (Publications)
binding activity as well as a decrease of C3 levels. Electronmicroscopic studies showed that the parasites were flagellated and localized extracellularly mainly in the interstitium of the choroid plexus [...] After treatment with ethidium bromide, trypanosomes persisted in the tissues when circulating parasites could no longer be detected. These observations suggest a sequential involvement of brain structures
Genomic distribution and functional characterisation of two distinct and conserved <em>Plasmodium falciparum</em> var gene 5' flanking sequences (Publications)
Approximately 50 highly diverse var genes distributed throughout the haploid genome of the malaria parasite Plasmodium falciparum code for PfEMP1 variants located on the surface of infected erythrocytes. [...] flanked by either type of 5' upstream sequence are transcribed in in vitro cultured trophozoite stage parasites. In addition, we have shown that the 5' flanking sequences of four different var genes are able
Effect of combined treatment with praziquantel and artemether on <em>Schistosoma japonicum </em>and<em> Schistosoma mansoni</em> in experimentally... (Publications)
safe and efficacious antischistosomal drugs that act against different developmental stages of the parasite: praziquantel against adult worms and artemether against schistosomula. A combined treatment has [...] control. Recent laboratory experiments with rabbits with a mixed infection of Schistosoma japonicum parasites of different ages confirmed the effectiveness of a combination therapy. In the present work, we
Synthesis of novel amide and urea derivatives of thiszol-2-ethylamines and their activity against<em> Trypanosoma brucei rhodesiense</em> (Publications)
the parasite was the urea analogue 2-(2-piperidin-1-ylamido)ethyl-4-(3-fluorophenyl)thiazole (70, IC50=9nM, SI> 18,000). None of 33 compounds tested were able to cure mice infected with the parasite; however
Micro-scale investigation of intestinal schistosomiasis transmission on Ngamba and Kimi islands, Lake Victoria, Uganda (Publications)
further research should also include surveys of terminal host parasite burden, as these will affect even micro-scale dynamics of parasite-intermediate host interactions, as well as be important from a
Associations of peak shifts in age-prevalence for human malarias with bednet coverage (Publications)
between the recent EIR and the parasite positivity for P. vivax. It is concluded that short-term variations in inoculation rate are not important determinants of parasite prevalence in this population.
