Prospective risk of morbidity in relation to multiplicity of infection with <em>Plasmodium falciparum </em>in Sao Tomé (Publications)
children aged 5-10 years. PCR-RFLP typing of the msp-2 gene of P. falciparum found a mean of 2.4 parasite genotypes per infected person, with little age dependence in this multiplicity and a total of 43 [...] consistent with suggestions that multiple P. falciparum infections may protect against super-infecting parasites, confounding by patterns of health service usage is an alternative explanation. The incidence of
A Trk/HKT-type K+ transporter from <em>Trypanosoma brucei</em> (Publications)
molecular mechanisms of K(+) homeostasis are only poorly understood for protozoan parasites. Trypanosoma brucei subsp. parasites, the causative agents of human sleeping sickness and nagana, are strictly ex
A new alkamide with an endoperoxide structure from <em>Acmella ciliata</em> (Asteraceae) and its <em>in vitro</em> antiplasmodial activity (Publications)
the minor constituent of the mixture. In vitro tests for activity against the human pathogenic parasites Trypanosoma brucei rhodesiense and Plasmodium falciparum revealed that 1 and 3 possess activity [...] tested against multiresistant P. falciparum K1 and was found to be even more active against this parasite strain (IC50 = 2.1 microM) with considerable selectivity (IC50 against L6 rat skeletal myoblasts
<em>P. falciparum</em> and <em>P. vivax</em> orthologous coiled-coil candidates for a potential cross-protective vaccine (Publications)
efforts are focused on the development of P. falciparum vaccines, the current availability of the parasite genomes, bioinformatics tools, and high throughput systems for both recombinant and synthetic antigen [...] antigen production have helped to accelerate vaccine development against the P. vivax parasite. We have previously in silico identified several P. falciparum and P. vivax proteins containing alpha-helical
<em>Plasmodium falciparum</em> merozoite surface protein 1 as asexual blood stage malaria vaccine candidate (Publications)
malaria vaccines might be key to reduce disease burden. Vaccines targeting asexual blood stages of the parasite have shown limited efficacy when studied in human trials conducted over the past decades. AREAS [...] benefit of including numerous conserved B-cell and T-cell epitopes. This could result in improved parasite strain-transcending, protective immunity in the field. We review here outcomes of clinical trials
Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent... (Publications)
use malaria rapid diagnostic tests (RDTs) to determine the proportion of the population carrying parasites in their peripheral blood to assess the malaria transmission intensity. Despite an increasing number [...] this study, 4.7% had a falsenegative result. These false-negative RDTs were associated with low parasite density infections. In 16.6% of analysed samples, masked pfhrp2 and pfhrp3 gene deletions were
The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing <em>Schistosoma mansoni</em> and hookworm co-infections... (Publications)
developed to compensate for the poor sensitivity, but the same is not true of any other helminth parasite, or infections with multiple-helminth species. We screened 101 schoolchildren from a rural area [...] respectively. In the current setting this could be attributable to low infection intensities of both parasites, combined with intra-specimen and day-to-day variation in egg output. If confirmed in other settings
Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis52 (Publications)
against protozoan parasites belonging to the genera Trypanosoma, Leishmania and Plasmodium. Among the tested compounds, naphthaldehyde 1 showed moderate inhibition of the growth of the parasites, T. brucei,
More than seven decades of <em>Acta Tropica</em>: looking back to move into the future (Publications)
scope of the journal broadened to the biology of pathogens and their vectors and genetics, host-parasite relationships, mechanisms of pathogenicity, diagnostics, and treatment of tropical diseases. The [...] re-emerging infectious diseases, epidemics and pandemics, interrelations of microbes, viruses, and parasites, co-dependencies of epidemiology, ecology, environment, and climate changes. Importantly, non-c
Antibodies elicited by a virosomally formulated <em>Plasmodium falciparum</em> serine repeat antigen-5 derived peptide detect the processed 47kDa... (Publications)
an appropriate sequence was crucial for the development of a peptide that elicited high titers of parasite cross-reactive antibodies in mice. Monoclonal antibodies (mAbs) raised against the optimized peptide [...] component for a multi-valent malaria subunit vaccine targeting both sporozoites and blood stage parasites
