Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent... (Publications)
use malaria rapid diagnostic tests (RDTs) to determine the proportion of the population carrying parasites in their peripheral blood to assess the malaria transmission intensity. Despite an increasing number [...] this study, 4.7% had a falsenegative result. These false-negative RDTs were associated with low parasite density infections. In 16.6% of analysed samples, masked pfhrp2 and pfhrp3 gene deletions were
More than seven decades of <em>Acta Tropica</em>: looking back to move into the future (Publications)
scope of the journal broadened to the biology of pathogens and their vectors and genetics, host-parasite relationships, mechanisms of pathogenicity, diagnostics, and treatment of tropical diseases. The [...] re-emerging infectious diseases, epidemics and pandemics, interrelations of microbes, viruses, and parasites, co-dependencies of epidemiology, ecology, environment, and climate changes. Importantly, non-c
In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in <em>Plasmodium... (Publications)
and artemisinin derivatives as well as the ozonide OZ277 (RBx11160 or arterolane) was evaluated in parasite cultures. The latter compound is an adamantane-based peroxide and the first fully synthetic clinical [...] indicating that activity of anti-malarial peroxides does not derive from reversible interactions with parasite targets
A high force of <em>Plasmodium vivax</em> blood-stage infection drives the rapid acquisition of immunity in Papua New Guinean children (Publications)
BACKGROUND: When both parasite species are co-endemic, Plasmodium vivax incidence peaks in younger children compared to P. falciparum. To identify differences in the number of blood stage infections of [...] values for P. falciparum. METHODS: P. vivax molFOB was estimated by high resolution genotyping parasites in samples collected over 16 months in a cohort of 264 Papua New Guinean children living in an area
The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing <em>Schistosoma mansoni</em> and hookworm co-infections... (Publications)
developed to compensate for the poor sensitivity, but the same is not true of any other helminth parasite, or infections with multiple-helminth species. We screened 101 schoolchildren from a rural area [...] respectively. In the current setting this could be attributable to low infection intensities of both parasites, combined with intra-specimen and day-to-day variation in egg output. If confirmed in other settings
Antibodies elicited by a virosomally formulated <em>Plasmodium falciparum</em> serine repeat antigen-5 derived peptide detect the processed 47kDa... (Publications)
an appropriate sequence was crucial for the development of a peptide that elicited high titers of parasite cross-reactive antibodies in mice. Monoclonal antibodies (mAbs) raised against the optimized peptide [...] component for a multi-valent malaria subunit vaccine targeting both sporozoites and blood stage parasites
Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania (Publications)
brucei and L. donovani amastigote-like forms, surpassing the activity of compound 3 against these parasites by 3.4- and 1.9-fold, respectively. Compound 35 inhibits the assembly of leishmanial tubulin with [...] 5-dinitro-N(4),N(4)-dialkylsulfanilamides a promising new class of antikinetoplastid agents that act on parasite tubulin
New developments in human African trypanosomiasis (Publications)
without parasite cultivation, eliminating a major impediment to efficient sampling for population studies. The finding that several wild animal species harbour T. b. gambiense, and that parasite transmission
<em>Strongyloides ratti</em>: in vitro and in vivo activity of tribendimidine (Publications)
third-stage larvae (L(3)) of Strongyloides ratti in vitro and against juvenile and adult stages of the parasite in vivo. S. ratti larvae incubated in PBS buffer containing 10-100 microg/ml tribendimidine died [...] administered to rats harboring a 2-day-old infection showed a moderate reduction of the intestinal parasite load. Three days post-exposure a significant reduction of the immature worm burden was found. A
Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis52 (Publications)
against protozoan parasites belonging to the genera Trypanosoma, Leishmania and Plasmodium. Among the tested compounds, naphthaldehyde 1 showed moderate inhibition of the growth of the parasites, T. brucei,
