<em>Plasmodium vivax</em> antigen discovery based on alpha-helical coiled coil protein motif (Publications)
blood-stage P. vivax parasites, and antigenic cross-reactivity with three of the peptides was observed when reacted with both the P. falciparum orthologous fragments and whole parasites. Results here point
Asymptomatic <em>Plasmodium falciparum</em> infections may not be shortened by acquired immunity (Publications)
The duration of untreated Plasmodium falciparum infections is a defining characteristic of the parasite's biology. It is not clear whether naturally acquired immunity (NAI) can shorten infections, despite [...] that this clearance may result from innate mechanisms or genetic incompatibility between hosts and parasites, rather than from NAI. CONCLUSION: In all ages of hosts a substantial proportion of infections are
<em>Plasmodium falciparum</em>: cloned and expressed CIDR domains of PfEMP1 bind to chondroitin sulfate A (Publications)
Adherence of erythrocytes infected with mature asexual Plasmodium falciparum parasites (iRBC) to microvascular endothelial cells contributes to the pathology of P. falciparum malaria. It has been shown [...] same region can also mediate binding to chondroitin sulfate A (CSA). CIDR domains of two different parasite strains were expressed in Escherichia coli as a 6xHis-tagged protein. Purified recombinant protein
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue (Publications)
blood schizonts of the malaria parasite P. falciparum in vitro. Furthermore, both compounds were active against the disease transmitting gametocyte forms of the parasites, which was systematically studied
Antiprotozoal, antitubercular and cytotoxic potential of cyanobacterial (blue-green algal) extracts from Ireland (Publications)
for R. biasolettiana extracts, and its chloroform sub-extract showed notable activity against all parasitic protozoa. There were differences in the biological activity profiles of extracts derived from desiccated [...] terrestrial cyanobacteria as a valuable source of new natural product leads for the treatment of parasitic protozoal infections
<em>Trypanosoma congolense</em> procyclins: unmasking cryptic major surface glycoproteins in procyclic forms (Publications)
In the tsetse fly, the protozoan parasite Trypanosoma congolense is covered by a dense layer of glycosylphosphatidylinositol (GPI)-anchored molecules. These include a protease-resistant surface molecule [...] 50 to 58 kDa, previously detected in procyclic culture forms, might constitute the coat of these parasites. We therefore partially purified the protein from T. congolense Kilifi procyclic forms, obtained
Malaria surveillance-response strategies in different transmission zones of the People's Republic of China: preparing for climate change (Publications)
the period 1961--2000 were prepared. Smoothed surface maps of the number of months suitable for parasite survival derived from monthly mean temperature and YRH were generated. For each decade, the final [...] malaria prediction map was overlaid by two mask maps, in terms of number of months suitable for parasite survival and YRH map in excess of 60%. RESULTS: Considering multiple environmental factors simu
<em>In vitro</em> and <em>in vivo</em> efficacy of mefloquine-based treatment against alveolar echinococcosis (Publications)
reduction of parasite weight, while treatment with albendazole (200mg/kg/day) was highly effective. However, when the same mefloquine dosage was applied intraperitoneally, the reduction in parasite weight was
<em>Plasmodium vivax</em> antigen discovery based on alpha-helical coiled coil protein motif (Publications)
blood-stage P. vivax parasites, and antigenic cross-reactivity with three of the peptides was observed when reacted with both the P. falciparum orthologous fragments and whole parasites. Results here point
Toxocara canis: a labile antigenic surface coat overlying the epicuticle of infective larvae (Publications)
gives a physical basis to earlier observations on the shedding of surface-bound antibodies by this parasite. An extracuticular surface coat has been demonstrated on Toxocara larvae prior to hatching from [...] during all stages of in vitro culture, suggesting that it may play a role both in protecting the parasite on hatching in the gastrointestinal tract and on subsequent tissue invasion in evading host immune
