The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue (Publications)
blood schizonts of the malaria parasite P. falciparum in vitro. Furthermore, both compounds were active against the disease transmitting gametocyte forms of the parasites, which was systematically studied
Antiprotozoal, antitubercular and cytotoxic potential of cyanobacterial (blue-green algal) extracts from Ireland (Publications)
for R. biasolettiana extracts, and its chloroform sub-extract showed notable activity against all parasitic protozoa. There were differences in the biological activity profiles of extracts derived from desiccated [...] terrestrial cyanobacteria as a valuable source of new natural product leads for the treatment of parasitic protozoal infections
Malaria surveillance-response strategies in different transmission zones of the People's Republic of China: preparing for climate change (Publications)
the period 1961--2000 were prepared. Smoothed surface maps of the number of months suitable for parasite survival derived from monthly mean temperature and YRH were generated. For each decade, the final [...] malaria prediction map was overlaid by two mask maps, in terms of number of months suitable for parasite survival and YRH map in excess of 60%. RESULTS: Considering multiple environmental factors simu
<em>Trypanosoma congolense</em> procyclins: unmasking cryptic major surface glycoproteins in procyclic forms (Publications)
In the tsetse fly, the protozoan parasite Trypanosoma congolense is covered by a dense layer of glycosylphosphatidylinositol (GPI)-anchored molecules. These include a protease-resistant surface molecule [...] 50 to 58 kDa, previously detected in procyclic culture forms, might constitute the coat of these parasites. We therefore partially purified the protein from T. congolense Kilifi procyclic forms, obtained
Asymptomatic <em>Plasmodium falciparum</em> infections may not be shortened by acquired immunity (Publications)
The duration of untreated Plasmodium falciparum infections is a defining characteristic of the parasite's biology. It is not clear whether naturally acquired immunity (NAI) can shorten infections, despite [...] that this clearance may result from innate mechanisms or genetic incompatibility between hosts and parasites, rather than from NAI. CONCLUSION: In all ages of hosts a substantial proportion of infections are
Spatiotemporal mapping of malaria incidence in Sudan using routine surveillance data (Publications)
due to factors including the rapidly developing resistance to drugs and insecticides among the parasites and vectors, respectively; the growing population living in humanitarian settings due to political [...] Anopheles stephensi in the country. These factors contribute to changes in the distribution of the parasites species as well as malaria vectors in Sudan, and the shifting patterns of malaria epidemiology
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 10. Effect of insecticide-treated bed nets on the dynamics of multiple... (Publications)
intervals of one month indicated that the average duration of infections, allowing for undetected parasite genotypes, was 73 d in those aged < 18 months and 160 d in children aged > or = 18 months, consistent [...] (SE = 6%) compared with 41% (SE = 6%) in older children. Conversely, the rate of appearance of new parasite genotypes was higher in children < 18 months of age than in older children, but this partly reflected
Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against <em>Trypanosoma... (Publications)
characterized for their dual-target antitrypanosomal profile, both in enzyme assays and in in vitro parasite cultures. The merged derivative 2-{[3-(3-dimethylaminopropoxy)-2-oxo-2H-chromen-7-yl]oxy}anthracene-1 [...] -yl]phenoxy}anthracene-1,4-dion e (compound 6) displayed a remarkable EC50 value for T. brucei parasites (0.026 muM) combined with a very low cytotoxicity toward mammalian L6 cells (7.95 muM). This promising
<em>In vitro</em> and <em>in vivo</em> efficacy of mefloquine-based treatment against alveolar echinococcosis (Publications)
reduction of parasite weight, while treatment with albendazole (200mg/kg/day) was highly effective. However, when the same mefloquine dosage was applied intraperitoneally, the reduction in parasite weight was
Paragonimiasis and its intermediate hosts in a transmission focus in Lao People's Democratic Republic (Publications)
Republic from several provinces, however, detailed descriptions of a focus of transmission including parasites species and intermediate hosts are lacking. Field investigations were carried out between February [...] Four dogs were infected with metacercaria and the species of the subsequently retrieved adult parasites were identified. 12.7% (15 cases) of all chronic cough patients (0.6% of the total population) suffered
