The antiprotozoal activity of methylated flavonoids from <em>Ageratum conyzoides</em> L (Publications)
prepared with solvents of different polarity were tested for activity against the above mentioned parasites as well as against Trypanosoma cruzi (Chagas' disease) and for cytotoxicity using established protocols [...] reported from Ageratum conyzoides. While the chromene turned out to be inactive against the tested parasites, the flavonoids showed activity against the protozoan pathogens, some in the lower micromolar range
Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to <em>Plasmodium</em> (Publications)
deliver drugs to Plasmodium-infected red blood cells (pRBCs) in order to limit the appearance of parasite resistance. Here, the poly(amidoamines) AGMA1 and ISA23 have been explored for the delivery of [...] preferential binding to and internalization into pRBCs vs. RBCs, and subcellular targeting to the parasite itself in widely diverging species such as P. falciparum and P. yoelii, infecting humans and mice
Metabolic alterations in the hamster co-infected with <em>Schistosoma japonicum</em> and <em>Necator americanus</em> (Publications)
d a combination of the altered metabolite profiles induced by single infections with these two parasites. Consistent differences in metabolic profiles between the co-infected and non-infected control hamsters [...] provide a first step towards understanding the metabolic response of an animal host to multiple parasitic infections
<em>Plasmodium falciparum</em>: cloned and expressed CIDR domains of PfEMP1 bind to chondroitin sulfate A (Publications)
Adherence of erythrocytes infected with mature asexual Plasmodium falciparum parasites (iRBC) to microvascular endothelial cells contributes to the pathology of P. falciparum malaria. It has been shown [...] same region can also mediate binding to chondroitin sulfate A (CSA). CIDR domains of two different parasite strains were expressed in Escherichia coli as a 6xHis-tagged protein. Purified recombinant protein
Comparative study of the effects of artemether and artesunate on juvenile and adult<em> Schistosoma mansoni</em> in experimentally infected mice (Publications)
comparatively the activity of both compounds against different developmental stages of schistosome parasites. Since artemisinin derivatives will be increasingly used to treat malaria, it is important to study [...] against schistosomes when they are used in malaria chemotherapy in areas of co-endemicity of both parasites.
Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine and mefloquine in <em>Schistosoma mansoni-</em>infected... (Publications)
praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with superior in vivo activity [...] in vitro, and the timing of its onset of action in vivo, it was postulated that immune-assisted parasite clearance could contribute to the drug's in vivo activity. We undertook histopathological studies
A spatially explicit model of the dynamics of <em>Opisthorchis viverrini </em>spread (Publications)
ABSTRACT Opisthorchis viverrini is a water-based disease-causing parasite whose public health implications are relevant in Southeast Asia. Untreated or chronic infections often lead to severe hepatobiliary [...] related scenarios of disease propagation through an improved description of the ecology of hosts, parasites and their transmission cycles. This work provides a more realistic description of the environment
Molecular epidemiology and seroprevalence in asymptomatic <em>Plasmodium falciparum</em> infections of Malagasy pregnant women in the highlands (Publications)
highlands, 67.4% of the women presented antibodies against Plasmodium falciparum and 9.2% were carrying parasites, at the coast 95.6% and 14.8%, respectively. In the mean, 1.2 clones were detected in infected pregnant [...] CONCLUSION: Immunity is triggered in Malagasy highland populations when they are infected with malaria parasites, but these populations could also serve as a reservoir for epidemics.
Assessing the effects of malaria interventions on the geographical distribution of parasitaemia risk in Burkina Faso (Publications)
survey collected among others, information on malaria interventions, treatment choices and malaria parasite prevalence in children aged 6-59 months. METHODS: In this study, Bayesian geostatistical models [...] spray (IRS), artemisinin-based combination therapy (ACT) coverage associated with childhood malaria parasite risk at national and sub-national level, after taking into account geographical disparities of
Amplicon deep sequencing improves <em>Plasmodium falciparum</em> genotyping in clinical trials of antimalarial drugs (Publications)
trials monitoring malaria drug resistance require genotyping of recurrent Plasmodium falciparum parasites to distinguish between treatment failure and new infection occurring during the trial follow up [...] ymorphic markers. AmpSeq was highly reproducible with consistent quantification of co-infecting parasite clones within a host. Outcomes of the three best-performing markers, cpmp, cpp and ama1-D3, agreed
