School children's intestinal parasite and nutritional status 1 year after complementary school garden, nutrition, water, sanitation, and hygiene... (Publications)
determine whether complementary school garden, nutrition, and WASH interventions reduce intestinal parasites and improve school children's nutritional status in two regions of Burkina Faso. A cluster-randomized [...] impact of the interventions, controlling for baseline characteristics. The prevalence of intestinal parasitic infections decreased both in intervention and control schools, but the decrease was significantly [...] delivered through the school platform improved several child...
<em>"Koko et les lunettes magiques"</em>: an educational entertainment tool to prevent parasitic worms and diarrheal diseases in Côte d'Ivoire (Publications)
food were the main causes of parasitic worm infections. Abdominal pain, diarrhea, lack of appetite, failure to grow, and general fatigue were mentioned as symptoms of parasitic worm infections. Most of the [...] conducted to assess the knowledge, attitudes, practices, and beliefs of school-aged children regarding parasitic worm infections and hygiene, to identify key health messages to be included in an animated cartoon [...] children knew that they should go to the hospital for treatment if...
Estimation of malaria parasite reservoir coverage using reactive case detection and active community fever screening from census data with rapid... (Publications)
conducted in southern Zambia to estimate the coverage of RCD or fDA in terms of the population and parasite reservoir as well as the operational requirements of such strategies, using a re-sampling algorithm [...] with search radii over several hundered meters will only yield limited coverage of the RDT positive parasite reservoir during a short period. Long-term use of these strategies may increase this proportion [...] radius. CONCLUSIONS: Reactive strategies in southern Zambia yield improved...
Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite... (Publications)
Transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by the intraerythrocytic gametocytes, which, once taken up during a blood meal, become activated to [...] to initiate sexual reproduction. Because gametocytes are the only parasite stages able to establish an infection in the mosquito, they are crucial for spreading the tropical disease. During gametocyte [...] of P. falciparum, little is known about this process during human-to-mosquito...
Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection (Publications)
BACKGROUND: During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe [...] cells - likewise disappear from circulation. Recent work has demonstrated that these sexual stage parasites are located in the hematopoietic system of the bone marrow before mature gametocytes are released [...] functional modules (clusters) of genes that are co-expressed primarily...
The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of <em>Plasmodium falciparum </em>viability after antimalarial... (Publications)
fast rate of parasite killing or clearance. To determine these parameters, it is essential to discriminate viable from nonviable parasites, which is complicated by the fact that viable parasites can be me [...] reliably discriminate between viable and nonviable parasites. Conversely, the in vitro parasite reduction ratio (PRR) assay is able to measure viable parasites with high sensitivity. It provides valuable p [...] With artemisinin-resistant Plasmodium falciparum parasites emerging in...
New <em>in vitro</em> interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations (Publications)
The development and spread of drug-resistant phenotypes substantially threaten malaria control efforts. Combination therapies have the potential to minimize the risk of resistance development but requ
Modulation of host-parasite interactions with small molecules targeting <em>Schistosoma mansoni </em>microRNAs (Publications)
Parasites use different strategies of communication with their hosts. One communication channel that has been studied in recent years is the use of vesicle microRNAs to influence the host immune system [...] approach by means of nuclear magnetic resonance (NMR) to identify binders to the precursor of the parasite sma-microRNA-10 present in their extracellular vesicles. The small fragments identified were used
