Toward organometallic antischistosomal drug candidates (Publications)
recent years, there has been a growing interest in the use of novel approaches for the treatment of parasitic diseases such as schistosomiasis. Among the different approaches used, organometallic compounds
Design and preparation of sterol mimetics as potential antiparasitics (Publications)
the azasterols. From this, two series of mimics were synthesised and then evaluated against the parasites. Compounds showed moderate activity
Synthesis of a potent antimalarial agent through natural products conjugation (Publications)
scaffolds and drugs, such as dihydroartemisinin (blue), potent activity against the blood-stage parasite can be seen both in vitro and in vivo. The compound shown exhibits an IC(50) value of 1.4 nM against
Meta-analysis: accuracy of rapid tests for malaria in travelers returning from endemic areas (Publications)
random-effects meta-analysis, stratified by the antigen targeted (histidine-rich protein-2 [HRP-2] or parasite lactate dehydrogenase [LDH]) and by test generation. Nomograms of post-test probabilities were [...] included 21 studies and 5747 individuals. For P. falciparum, HRP-2-based tests were more accurate than parasite LDH-based tests: Negative likelihood ratios were 0.08 and 0.13, respectively (P = 0.019 for difference) [...] For P. vivax, negative likelihood ratios tended to be closer to...
Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
described, including its spectrum of activities against multiple life cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo [...] vivo efficacies in two murine malaria models that permit infection with the human and the rodent parasites P. falciparum and Plasmodium berghei, respectively. In vitro, ACT-451840 showed a 50% inhibition [...] harbor additional gametocytocidal activity and, thereby,...
Gametocyte carriage in uncomplicated <em>Plasmodium falciparum</em> malaria following treatment with artemisinin combination therapy: a systematic... (Publications)
Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important [...] microscopy at enrolment was 12.1 % (5887/48,589), and increased with decreasing age, decreasing asexual parasite density and decreasing haemoglobin concentration, and was higher in patients without fever at p [...] 90; P < 0.001) and new (AOR, 3.03; 95 % CI, 1.66-5.54; P < 0.001)...
Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
described, including its spectrum of activities against multiple life cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo [...] vivo efficacies in two murine malaria models that permit infection with the human and the rodent parasites P. falciparum and Plasmodium berghei, respectively. In vitro, ACT-451840 showed a 50% inhibition [...] harbor additional gametocytocidal activity and, thereby,...
Gametocyte carriage in uncomplicated <em>Plasmodium falciparum</em> malaria following treatment with artemisinin combination therapy: a systematic... (Publications)
Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important [...] microscopy at enrolment was 12.1 % (5887/48,589), and increased with decreasing age, decreasing asexual parasite density and decreasing haemoglobin concentration, and was higher in patients without fever at p [...] 90; P < 0.001) and new (AOR, 3.03; 95 % CI, 1.66-5.54; P < 0.001)...
Current Recommended Treatment against Whipworm Shows Better Results than New Drug Combination (News)
https://www.swisstph.ch/en/news/news-detail/news/current-recommended-treatment-against-whipworm-shows-better-results-than-new-drug-combination
these detrimental effects. Soil-transmitted helminth infections are caused by several species of parasitic worms. One of them is the whipworm Trichuris trichiura . Limitations of current drugs Given their [...] of choice are albendazole and mebendazole. "While these drugs show mostly good results in other parasitic worm infections, they are unsatisfactory in Trichuris trichiura infections," said Jennifer Keiser [...] ivermectin administration,” said Keiser. Moreover, moxidectin can also be used...
A new chemotype with promise against <em>Trypanosoma cruzi</em> (Publications)
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of > /=10. The initial structure-activity relationship (SAR) indicates that
