Improving methods for analysing anti-malarial drug efficacy trials: molecular correction based on length-polymorphic markers <em>msp</em>-1,... (Publications)
failures, and patients are frequently re-infected during that period. Molecular correction based on parasite genotypes distinguishes reinfections from drug failures to ensure the accuracy of failure rate estimates [...] most accurate and/or robust remains unknown. METHODS: We used pharmacological modelling to simulate parasite dynamics and genetic signals that occur in patients enrolled in malaria drug clinical trials. We
Human African Tryponosomiasis | SwissTPH (Page)
https://www.swisstph.ch/en/topics/sleeping-sickness
decades, Swiss TPH has been at the forefront of developing innovative ways to combat the deadly parasites responsible for the disease. Over the past decade, our researchers have identified dozens of highly [...] remote regions of sub-Saharan Africa and primarily affects the poorest populations. The protozoan parasite that causes the disease, Trypanosoma brucei gambiense, is transmitted to humans by the tsetse fly [...] is generally fatal. After the initial phase of non-specific pain, fever, rash...
Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites (Publications)
and ?2-fold increased activities against drug-sensitive and drug-resistant Plasmodium falciparum parasites.
In vitro and in vivo treatments of <em>Echinococcus </em>protoscoleces and metacestodes with artemisinin and artemisinin derivatives (Publications)
both drugs with albendazole led to a substantial but statistically not significant reduction in parasite weight compared to results with albendazole alone
[(eta(6) -praziquantel)Cr(CO)(3)] derivatives with remarkable in vitro anti-schistosomal activity (Publications)
available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and had only a minor cytotoxic effect on selected mammalian cell lines
3-hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure <em>P. berghei</em> infected mice when administered... (Publications)
subnanomolar antiplasmodial activity against asexual blood stages of Plasmodium falciparum, excellent parasite selectivity, and nanomolar activity against the earliest forms of gametocyte development. Particularly
Neue Parameter für die Wirkstofftestung gegen <em>Trypanosoma cruzi</em> (Publications)
chronic stage. This is where high-content imaging makes a key contribution: assays with fluorescent parasites in cell culture allow to determine pharmacodynamic parameters and to better assess the antichagasic
Malaria websites (Publications)
post-travel advice and management of travelers with illness upon return, 2) the essential on the parasite, the diagnosis and the treatment, 3) the malaria problem worldwide and 4) malaria maps
Spinal cystic echinococcosis - a systematic analysis and review of the literature: part 1. Epidemiology and anatomy (Publications)
techniques as well as surgical and medical treatment of spinal CE, our basic understanding of the parasite's predilection for the spine remains incomplete. To fill this gap, we systematically reviewed the
Synthetic GPI array to study antitoxic malaria response (Publications)
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI
