Augustamine type alkaloids from <em>Crinum kirkii</em> (Publications)
2-Diacetyllycorine and 3-O-acetylsanguinine showed activity against Trypanosoma brucci rhodesiense, the parasite associated with sleeping sickness. 3-O-acetylsanguinine also showed some activity against Trypanosoma
Topoisomerases in kinetoplastids (Publications)
variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA
Durchfälle durch Parasiten (Publications)
The role of parasites as etiologic agents in diarrhea is emphasized. In countries of western Europe, Entamoeba histolytica and Giardia lamblia are the most prevalent species, although some other 20 protozoans
Inhibitors of Plasmepsin II-potential antimalarial agents (Publications)
targeting Plasmepsin II, a Plasmodium falciparum aspartic protease active in hemoglobin degradation, a parasite specific catabolic pathway. The results show that the new structural class is not only inhibiting
Topoisomerases in kinetoplastids (Publications)
variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA
Augustamine type alkaloids from <em>Crinum kirkii</em> (Publications)
2-Diacetyllycorine and 3-O-acetylsanguinine showed activity against Trypanosoma brucci rhodesiense, the parasite associated with sleeping sickness. 3-O-acetylsanguinine also showed some activity against Trypanosoma
Durchfälle durch Parasiten (Publications)
The role of parasites as etiologic agents in diarrhea is emphasized. In countries of western Europe, Entamoeba histolytica and Giardia lamblia are the most prevalent species, although some other 20 protozoans
Total synthesis and antitrypanosomal activity of janadolide and simplified analogues (Publications)
antitrypanosomal activity against pathogenic Trypanosoma brucei rhodesiense and Trypanosoma cruzi parasites.
Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI (Publications)
the corresponding amidines (15a-c). The new amidines were evaluated in vitro against the protozoan parasite Trypanosoma brucei rhodesiense (T. b. r.). The thiophene analogue 5b and the N-methyl compound 15a
The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)
from P. falciparum TEX1 blood-stage protein found to be the target of human antibodies inhibiting parasite growth. The present project aimed at evaluating the safety and immunogenicity of P27A peptide vaccine [...] marked specific antibody response able to recognize TEX1 in infected erythrocytes and to inhibit parasite growth through an ADCI dependent mechanism. Incidence of AEs and antibody responses were significantly
