Searched for parasites.

1. Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker (Publications)

   Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

   Relevance:

   depletor) through a cleavable amide bond in order to target two essential pathways in the malarial parasites. The results showed no enhancement of the antimalarial activity of the dual molecules but evidenced

2. Die Bedeutung der Anamnese bei Erkrankungen nach Tropenaufenthalt (Publications)

   Die Bedeutung der Anamnese bei Erkrankungen nach Tropenaufenthalt

   Relevance:

   the first symptoms is related to the course of tropical diseases, prepatency and survival time of parasites

3. Antiprotozoal activities of epimeric aminobicycles (Publications)

   Antiprotozoal activities of epimeric aminobicycles

   Relevance:

   organism of East African sleeping sickness, and Plasmodium falciparum K-1, a multiresistant protozoan parasite which causes Malaria tropica. The results are compared to the activities of their formerly synthesized

4. Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker (Publications)

   Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

   Relevance:

   depletor) through a cleavable amide bond in order to target two essential pathways in the malarial parasites. The results showed no enhancement of the antimalarial activity of the dual molecules but evidenced

5. Diamidines for human African trypanosomiasis (Publications)

   Diamidines for human African trypanosomiasis

   Relevance:

   drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design

6. Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents (Publications)

   Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents

   Relevance:

   activity against the chloroquine-sensitive NF54 and multidrug-resistant K1 strains of the malarial parasite Plasmodium falciparum. Most of these derivatives showed a 4-49 and 5-17-fold increase in activity

7. Never seen before? Opisthorchiasis and Clonorchiasis (Publications)

   Never seen before? Opisthorchiasis and Clonorchiasis

   Relevance:

   Parasitic diseases are relatively rarely diagnosed and treated in Europe. Therefore, European clinicians are not familiar with their clinical and imaging features. In an era of increased human migration

8. Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones (Publications)

   Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones

   Relevance:

   Chagas' disease, caused by Trypanosoma cruzi(T. cruzi), is one of the most serious parasitic diseases in Latin America. The currently available chemotherapy, based on nifurtimox or benznidazole, is un

9. <em>In vitro</em> antiprotozoal activity of alkaloids from <em>Phaedranassa dubia</em> (Amaryllidaceae) (Publications)

   <em>In vitro</em> antiprotozoal activity of alkaloids from <em>Phaedranassa dubia</em> (Amaryllidaceae)

   Relevance:

   determined by physical and spectroscopic methods. An in vitro screening against four different parasitic protozoa was carried out using the isolated compounds. The alkaloids ungeremine, pseudolycorine

10. Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)

    Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase

    Relevance:

    presence of a substituent had a small or negative effect on activity against the enzyme or intact parasites compared to unsubstituted compounds