Country specific predictions of the cost-effectiveness of malaria vaccine RTS,S/AS01 in endemic Africa (Publications)
follow-up data from the phase 3 trial, vaccine effectiveness was evaluated at country levels of malaria parasite prevalence, coverage of control interventions and immunization. Benefits and costs of the program [...] 448) per DALY averted; the ratio is lower by one third - $136 (range $116-$220) - in settings where parasite prevalence in children aged 2-10years is at or above 10%. CONCLUSION: RTS,S/AS01has the potential
From <em>Plasmodium vivax</em> outbreak to elimination: lessons learnt from a retrospective analysis of data from Guantang (Publications)
from 1971-1995, were digitized. The data included monthly numbers of reported cases, febrile cases, parasite carriage rates, the neonatal infection rate, and entomological data regarding Anopheles sinensis [...] 1992-1995. Some fluctuations in incidence were observed between 1977 and 1981. During the period parasite rates, antibody levels and the neonatal infection rate also decreased. The pattern of seasonality
Pathogens that cause acute febrile illness among children and adolescents in Burkina Faso, Madagascar and Sudan (Publications)
chain reaction (PCR)-based TaqMan-Array Card designed to detect a panel of bacterial, viral and parasitic pathogens. Clinical metadata were also assessed. RESULTS: A total of 615 blood samples available [...] exerting likely activity. CONCLUSIONS: A PCR-approach for identifying multiple bacterial, viral and parasitic pathogens in whole blood unveiled a diversity of previously undetected pathogens in AFI cases and
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for differential identification of adult <em>Schistosoma </em>worms (Publications)
worldwide. The diagnosis of human schistosomiasis is mainly based on the microscopic detection of the parasite's eggs in the feces (i.e., for Schistosoma mansoni or Schistosoma japonicum) or urine (i.e., for [...] many microbiological laboratories. Preliminary studies have recently shown promising results for parasite identification using this method. The aims of this study were to develop and validate a species-specific
37 years of forest monitoring in Switzerland: drought effects on<em> Fagus sylvatica</em> (Publications)
transparency. The delay in mortality after the weakening event suggests also the importance of weakness parasites. The staining of active vessels with safranine revealed that the cavitation caused by the low tree [...] consequence of closed stomata and P deficiency (photooxidation) and (iii) infestation with weakness parasites (beech bark disease and root rots).
Molecular detection and genetic characterization of zoonotic hookworm in semi-domesticated cats residing in monasteries in Bangkok, Thailand (Publications)
Hookworms are the most common parasitic nematodes in the genus of Ancylostoma that infect both humans and animals in subtropical and tropical South East Asia. The common hookworm species in cats is Ancylostoma [...] and dogs. The findings show that temple cats can act as a potential source of zoonotic hookworm parasites for the human and animal population in Bangkok, Thailand. Therefore, appropriate control measures
The epidemiology of polyparasitism and implications for morbidity in two rural communities of Côte d'Ivoire (Publications)
m and implications for morbidity are poorly understood. We studied patterns of multiple species parasite infection in two rural communities of Cote d'Ivoire, including associations and interactions between [...] Multivariate logistic regression models were applied for assessment of possible associations between parasitic (co-)infections and morbidity outcomes. RESULTS: 912/1,095 (83.3%) study participants had complete
The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus... (Publications)
treatment failure rate in the two sites was reflected in the corresponding genetic profile of the parasite populations, with significant differences seen in the allele frequencies of mutant pfmdr1 N86Y, [...] PNG and indicates which of the many molecular markers analysed are useful for the monitoring of parasite resistance to combinations with AQ+SP
Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by <em>Trypanosoma brucei gambiense</em>: a randomised... (Publications)
BACKGROUND: African trypanosomiasis is a fatal disease caused by protozoan parasites of the species Trypanosoma brucei. The disease has reached epidemic dimensions in various countries of central Africa [...] schedule comprised 10 daily injections of 2.2 mg/kg. Primary outcomes assessed were elimination of parasites, deaths attributed to treatment, and rate of encephalopathy. Analysis was by intention to treat
<em>Plasmodium falciparum</em> heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors (Publications)
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by [...] majority of P. falciparum lineage-specific gene families coding for exported proteins involved in host-parasite interactions. In addition, we identified a number of PfHP1-bound genes that were not enriched in
