Distribution and risk factors for <em>Plasmodium</em> and helminth co-infections: a cross-sectional survey among children in Bagamoyo district,... (Publications)
particularly among children. There are conflicting findings on potential association between these two parasites. This study investigated the Plasmodium and helminth co-infections among children aged 2 months [...] (e.g., ivermectin) coupled with improved housing, sanitation and hygiene for the control of both parasitic infections
From <em>Plasmodium vivax</em> outbreak to elimination: lessons learnt from a retrospective analysis of data from Guantang (Publications)
from 1971-1995, were digitized. The data included monthly numbers of reported cases, febrile cases, parasite carriage rates, the neonatal infection rate, and entomological data regarding Anopheles sinensis [...] 1992-1995. Some fluctuations in incidence were observed between 1977 and 1981. During the period parasite rates, antibody levels and the neonatal infection rate also decreased. The pattern of seasonality
The epidemiology of polyparasitism and implications for morbidity in two rural communities of Côte d'Ivoire (Publications)
m and implications for morbidity are poorly understood. We studied patterns of multiple species parasite infection in two rural communities of Cote d'Ivoire, including associations and interactions between [...] Multivariate logistic regression models were applied for assessment of possible associations between parasitic (co-)infections and morbidity outcomes. RESULTS: 912/1,095 (83.3%) study participants had complete
37 years of forest monitoring in Switzerland: drought effects on<em> Fagus sylvatica</em> (Publications)
transparency. The delay in mortality after the weakening event suggests also the importance of weakness parasites. The staining of active vessels with safranine revealed that the cavitation caused by the low tree [...] consequence of closed stomata and P deficiency (photooxidation) and (iii) infestation with weakness parasites (beech bark disease and root rots).
The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus... (Publications)
treatment failure rate in the two sites was reflected in the corresponding genetic profile of the parasite populations, with significant differences seen in the allele frequencies of mutant pfmdr1 N86Y, [...] PNG and indicates which of the many molecular markers analysed are useful for the monitoring of parasite resistance to combinations with AQ+SP
<em>Plasmodium falciparum</em> heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors (Publications)
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by [...] majority of P. falciparum lineage-specific gene families coding for exported proteins involved in host-parasite interactions. In addition, we identified a number of PfHP1-bound genes that were not enriched in
Pathogens that cause acute febrile illness among children and adolescents in Burkina Faso, Madagascar and Sudan (Publications)
chain reaction (PCR)-based TaqMan-Array Card designed to detect a panel of bacterial, viral and parasitic pathogens. Clinical metadata were also assessed. RESULTS: A total of 615 blood samples available [...] exerting likely activity. CONCLUSIONS: A PCR-approach for identifying multiple bacterial, viral and parasitic pathogens in whole blood unveiled a diversity of previously undetected pathogens in AFI cases and
Distribution and risk factors for <em>Plasmodium</em> and helminth co-infections: a cross-sectional survey among children in Bagamoyo district,... (Publications)
particularly among children. There are conflicting findings on potential association between these two parasites. This study investigated the Plasmodium and helminth co-infections among children aged 2 months [...] (e.g., ivermectin) coupled with improved housing, sanitation and hygiene for the control of both parasitic infections
Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the <em>P. vivax</em> circumsporozoite protein (Publications)
Plasmodium vivax circumsporozoite (PvCS) protein is a major sporozoite surface antigen involved in parasite invasion of hepatocytes and is currently being considered as vaccine candidate. PvCS contains a [...] order to assess the humoral and cellular immune responses as well as protective efficacy against parasite challenge of the vaccine candidate must be conducted.
Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by <em>Trypanosoma brucei gambiense</em>: a randomised... (Publications)
BACKGROUND: African trypanosomiasis is a fatal disease caused by protozoan parasites of the species Trypanosoma brucei. The disease has reached epidemic dimensions in various countries of central Africa [...] schedule comprised 10 daily injections of 2.2 mg/kg. Primary outcomes assessed were elimination of parasites, deaths attributed to treatment, and rate of encephalopathy. Analysis was by intention to treat
