Country specific predictions of the cost-effectiveness of malaria vaccine RTS,S/AS01 in endemic Africa (Publications)
follow-up data from the phase 3 trial, vaccine effectiveness was evaluated at country levels of malaria parasite prevalence, coverage of control interventions and immunization. Benefits and costs of the program [...] 448) per DALY averted; the ratio is lower by one third - $136 (range $116-$220) - in settings where parasite prevalence in children aged 2-10years is at or above 10%. CONCLUSION: RTS,S/AS01has the potential
Antiprotozoal aminosteroids from <em>Pachysandra terminalis</em> (Publications)
Trypanosoma brucei rhodesiense (Tbr) and Plasmodium falciparum (Pf) are protozoan parasites that cause severe diseases, namely, Human African Trypanosomiasis (HAT) and Malaria. Due to limited treatment [...] alkaloid-enriched fraction of P. terminalis aerial parts showed promising activity against protozoan parasites. In the present study, the alkaloid-enriched fraction obtained from a 75% ethanol extract of aerial
PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults (Publications)
exposed healthy adults. Vaccine-induced protection presumably depends on cellular responses to early parasite liver stages, but humoral immunity contributes. METHODS: On custom-made Pf protein microarrays, [...] without (n = 9) HIV infection. Expression of the main identified immunogens in the pre-erythrocytic parasite stage was verified by immunofluorescence detection using freshly purified PfSPZ and an in vitro
<em>Blastocystis</em> in Swiss children: a practical approach (Publications)
Blastocystis is a parasite with a worldwide distribution and a varying prevalence in different countries. The pleomorphic nature of the protozoon and the lack of understanding a possible pathogenesis have [...] by Entamoeba coli (8%), 26.3% of the patients with Blastocystis had a co-infection with another parasite, mostly Endolimax nana (13%).Conclusion: Carriage of Blastocystis is common; therefore, only ch
Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole (Publications)
lic compounds on a very broad range of parasitic helminths and protozoan, is a clear confirmation of the potential of organometallic complexes against parasites of medical and veterinary importance.
Malaria Mortality in Africa May Be Higher than Estimated (News)
https://www.swisstph.ch/en/news/news-detail/news/malaria-mortality-in-africa-may-be-higher-than-estimated
taken into account indirect deaths from malaria such as anaemia. Studies also mainly used malaria parasite prevalence as a key measure, which is not directly linked to severe malaria and thus death. "To [...] PhD candidate at Swiss TPH and first author of the study. "We were able to confirm that malaria parasite prevalence alone fails to fully capture the association with mortality. The malaria-anaemia comorbidity
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for differential identification of adult <em>Schistosoma </em>worms (Publications)
worldwide. The diagnosis of human schistosomiasis is mainly based on the microscopic detection of the parasite's eggs in the feces (i.e., for Schistosoma mansoni or Schistosoma japonicum) or urine (i.e., for [...] many microbiological laboratories. Preliminary studies have recently shown promising results for parasite identification using this method. The aims of this study were to develop and validate a species-specific
Molecular detection and genetic characterization of zoonotic hookworm in semi-domesticated cats residing in monasteries in Bangkok, Thailand (Publications)
Hookworms are the most common parasitic nematodes in the genus of Ancylostoma that infect both humans and animals in subtropical and tropical South East Asia. The common hookworm species in cats is Ancylostoma [...] and dogs. The findings show that temple cats can act as a potential source of zoonotic hookworm parasites for the human and animal population in Bangkok, Thailand. Therefore, appropriate control measures
Improving antichagasic drug discovery through stage-specific monitoring of Trypanosoma cruzi (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/improving-antichagasic-drug-discovery-through-stage-specific-monitoring-of-trypanosoma-cruzi
About 6-7 million people are infected with Trypanosoma cruzi , a protozoan parasite causing Chagas’ disease. Most of the symptoms appear in the chronic phase of Chagas’ disease: cardiomyopathies and m [...] differentiation and the effect of drugs on these processes. Such read-outs require transgenic parasites with reporter genes. For this purpose, we have phenotypically characterized a clonal T. cruzi line
Discovery and optimization of a compound series active against <em>Trypanosoma cruzi</em>, the causative agent of chagas disease (Publications)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically
