Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole (Publications)
cotrimoxazole group 47.8%. These results indicate that berberine is more effective in clearing the parasite than both tetracycline and cotrimoxazole, and that the combination of pyrimethamine and berberine
Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones (Publications)
rhodesiense and American T. cruzi was investigated. All tested compounds were found active towards both parasites, the former being generally more sensitive. Helenalin was the most active compound in the series
Phenotypic screening of histone deacetylase (HDAC) inhibitors against <em>Schistosoma mansoni</em> (Publications)
Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses
Trematode infections: liver and lung flukes (Publications)
lung, and intestinal flukes. This article focuses on the most important liver and lung flukes that parasitize man, namely Clonorchis sinensis, Fasciola gigantica, Fasciola hepatica, Opisthorchis felineus,
Cultivation of procyclic trypomastigotes of <em>Trypanosoma congolense</em> in a semi-defined medium with direct adaptation from bloodstream forms (Publications)
procyclic trypomastigotes. Established cultures of the procyclic forms yielded up to 4.5 X 10(7) parasites/ml. The cultivated populations consisted only of trypomastigotes and were not infective for mice
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with
Novel real-time PCR for the universal detection of <em>Strongyloides spp</em> (Publications)
was one larvae per PCR reaction. The assay proved to be 100% specific as assessed by a panel of parasites and bacteria and thus might be useful in the diagnostic setting as well as for strongyloides research
Trematode infections: liver and lung flukes (Publications)
lung, and intestinal flukes. This article focuses on the most important liver and lung flukes that parasitize man, namely Clonorchis sinensis, Fasciola gigantica, Fasciola hepatica, Opisthorchis felineus,
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with
Cultivation of procyclic trypomastigotes of <em>Trypanosoma congolense</em> in a semi-defined medium with direct adaptation from bloodstream forms (Publications)
procyclic trypomastigotes. Established cultures of the procyclic forms yielded up to 4.5 X 10(7) parasites/ml. The cultivated populations consisted only of trypomastigotes and were not infective for mice
