Phenotypic screening of histone deacetylase (HDAC) inhibitors against <em>Schistosoma mansoni</em> (Publications)
Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses
Novel real-time PCR for the universal detection of <em>Strongyloides spp</em> (Publications)
was one larvae per PCR reaction. The assay proved to be 100% specific as assessed by a panel of parasites and bacteria and thus might be useful in the diagnostic setting as well as for strongyloides research
Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones (Publications)
rhodesiense and American T. cruzi was investigated. All tested compounds were found active towards both parasites, the former being generally more sensitive. Helenalin was the most active compound in the series
Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole (Publications)
cotrimoxazole group 47.8%. These results indicate that berberine is more effective in clearing the parasite than both tetracycline and cotrimoxazole, and that the combination of pyrimethamine and berberine
Discovery and optimization of a compound series active against <em>Trypanosoma cruzi</em>, the causative agent of chagas disease (Publications)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically
Novel 4-[4-(4-methylpiperazin-1-yl)phenyl]-6-arylpyrimidine derivatives and their antitrypanosomal activities against <em>T.brucei</em> (Publications)
is invariably fatal unless treated. Current therapies present limitations in their application, parasite resistance, or require further clinical investigation for wider use. Our work, informed by previous
One hundred years of Suramin (Publications)
rhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite and autism. Suramin is also an enigmatic molecule: What
Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge <em>Pandaros acanthifolium</em> (Publications)
previous metabolites of this family. All new compounds showed moderate to weak activity against four parasitic protozoa. Additionally, these compounds and previously reported pandarosides and acanthifoliosides
The changing epidemiology of malaria in Ifakara Town, southern Tanzania (Publications)
involving children up to the age of 5 years. There was a right shift and lowering in the age-specific parasite prevalence in the community-based cohort studies. The incidence of clinical malaria in placebo-receiving
Modified 5'-trityl nucleosides as inhibitors of <em>Plasmodium falciparum</em> dUTPase (Publications)
deoxyuridine, and modifications of the base. Compounds were tested against both the enzyme and the parasite. Variations of the 5'-trityl group and of the 3'-substituent were well tolerated and yielded active
