Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness (Publications)
randomised clinical equivalence trial of 500 patients in Angola. 24 h after treatment, all patients were parasite free. Of 442 patients, 12 (3%) had relapsed after 1 year, of whom seven (3%) had had standard treatment
Novel nucleoside-based antimalarial compounds (Publications)
The malaria-causing parasite Plasmodium falciparum employs a salvage pathway for the biosynthesis of nucleotides, in contrast to de novo biosynthesis that is utilized by the human host. A series of twenty-two
Case report: gnathostomiasis acquired in Costa Rica in a returning traveler to the United Kingdom (Publications)
Gnathostomiasis, caused by infection with nematode parasites in the genus Gnathostoma, is endemic in tropical and temperate zones, and is classically associated with East and Southeast Asia and, more recently
The malaria vaccine development programme in Papua New Guinea (Publications)
and ring-infected erythrocyte surface antigen (RESA)], which led to a considerable reduction of parasite density in the immunized children
The impact of <em>Loa loa</em> microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea (Publications)
malaria vaccine clinical trial. Only one subject was found to have microfilaraemia on his first exam; parasites were not discovered in the other seven until subsequent TBSs were performed, at times many weeks
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents (Publications)
the sterol 14alpha-demethylase (T. cruzi CYP51) enzyme. Because combination treatments against parasites are often superior to monotherapy, we believe that this emerging class of bifunctional compounds
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in <em>Plasmodium falciparum</em> (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
focusing on Plasmodium falciparum and Plasmodium vivax. Second, we describe and compare different parasite genotyping methods commonly used in malaria epidemiology and population genetics. Finally, we discuss
Case report: gnathostomiasis acquired in Costa Rica in a returning traveler to the United Kingdom (Publications)
Gnathostomiasis, caused by infection with nematode parasites in the genus Gnathostoma, is endemic in tropical and temperate zones, and is classically associated with East and Southeast Asia and, more recently
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents (Publications)
the sterol 14alpha-demethylase (T. cruzi CYP51) enzyme. Because combination treatments against parasites are often superior to monotherapy, we believe that this emerging class of bifunctional compounds
