The malaria vaccine development programme in Papua New Guinea (Publications)
and ring-infected erythrocyte surface antigen (RESA)], which led to a considerable reduction of parasite density in the immunized children
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
focusing on Plasmodium falciparum and Plasmodium vivax. Second, we describe and compare different parasite genotyping methods commonly used in malaria epidemiology and population genetics. Finally, we discuss
The impact of <em>Loa loa</em> microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea (Publications)
malaria vaccine clinical trial. Only one subject was found to have microfilaraemia on his first exam; parasites were not discovered in the other seven until subsequent TBSs were performed, at times many weeks
Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness (Publications)
randomised clinical equivalence trial of 500 patients in Angola. 24 h after treatment, all patients were parasite free. Of 442 patients, 12 (3%) had relapsed after 1 year, of whom seven (3%) had had standard treatment
The changing epidemiology of malaria in Ifakara Town, southern Tanzania (Publications)
involving children up to the age of 5 years. There was a right shift and lowering in the age-specific parasite prevalence in the community-based cohort studies. The incidence of clinical malaria in placebo-receiving
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in <em>Plasmodium falciparum</em> (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate
Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge <em>Pandaros acanthifolium</em> (Publications)
previous metabolites of this family. All new compounds showed moderate to weak activity against four parasitic protozoa. Additionally, these compounds and previously reported pandarosides and acanthifoliosides
Modified 5'-trityl nucleosides as inhibitors of <em>Plasmodium falciparum</em> dUTPase (Publications)
deoxyuridine, and modifications of the base. Compounds were tested against both the enzyme and the parasite. Variations of the 5'-trityl group and of the 3'-substituent were well tolerated and yielded active
Novel nucleoside-based antimalarial compounds (Publications)
The malaria-causing parasite Plasmodium falciparum employs a salvage pathway for the biosynthesis of nucleotides, in contrast to de novo biosynthesis that is utilized by the human host. A series of twenty-two
One hundred years of Suramin (Publications)
rhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite and autism. Suramin is also an enigmatic molecule: What
