Novel 4-[4-(4-methylpiperazin-1-yl)phenyl]-6-arylpyrimidine derivatives and their antitrypanosomal activities against <em>T.brucei</em> (Publications)
is invariably fatal unless treated. Current therapies present limitations in their application, parasite resistance, or require further clinical investigation for wider use. Our work, informed by previous
Disease, activity and schoolchildren's health (DASH) in Port Elizabeth, South Africa: a study protocol (Publications)
BACKGROUND: An in-depth epidemiological investigation on intestinal parasite infections in an impoverished area of Port Elizabeth, South Africa provides a unique opportunity for research on its impact [...] performance and psychosocial health will be assessed. After each survey, individuals diagnosed with parasitic worm infections will be treated with anthelminthic drugs, while children with other infections will
A duplex tetra-primer ARMS-PCR assay to discriminate three species of the <em>Schistosoma haematobium</em> group: <em>Schistosoma curassoni, S. bovis,... (Publications)
three Schistosoma species, namely Schistosoma haematobium (human parasite), Schistosoma bovis and Schistosoma curassoni (animal parasites), and their hybrids. This technique will facilitate studies of
Potential drivers for schistosomiasis persistence: population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial... (Publications)
Key to meeting this goal is elucidating how selective pressures imposed by interventions shape parasite populations. Our aim was to identify any differential impact of a unique cluster-randomized tri-armed [...] reduced diversity and altered inbreeding over time. The greatest differences overall, both in terms of parasite fecundity and genetic sub-structuring, were observed between the islands, consistent with Pemba's
High prevalence of urinary schistosomiasis in a desert population: results from an exploratory study around the Ounianga lakes in Chad (Publications)
study focusing on the lakes of Ounianga in Northern Chad. The aim was to test whether trematode parasites such as Schistosoma spp occur in human populations living around the Sahara desert lakes of Ounianga [...] behaviour; and third, searching water contact sites for intermediate host snails. Samples of trematode parasites and snails were confirmed on species level by molecular genetics methods. Results: Among 258 pa
Artemether-lumefantrine treatment of uncomplicated <em>Plasmodium falciparum</em> malaria: a systematic review and meta-analysis of day 7 lumefantrine... (Publications)
lumefantrine concentration threshold needs to be defined better, particularly for important patient and parasite sub-populations. METHODS: The WorldWide Antimalarial Resistance Network (WWARN) conducted a large [...] patients with high parasitemias; and patients in very low transmission intensity areas with emerging parasite resistance. In these groups, adherence and treatment response should be monitored closely. Higher
Optimization and validation of multi-coloured capillary electrophoresis for genotyping of <em>Plasmodium falciparum</em> merozoite surface proteins... (Publications)
essential in anti-malarial drug trials to define treatment outcome, by distinguishing recrudescent parasites from new infections. Because of the limitations in specificity and resolution of gel electrophoresis [...] malaria infected children, compared to gel electrophoresis. The capacity to distinguish recrudescent parasites from new infections in an anti-malarial drug trial was similar by both methods, resulting in the
Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission (Publications)
property may complement the effect of terminating otherwise lengthy malaria infections and reducing the parasite reservoir in the human population that can infect vector mosquitoes. However, this has never been [...] tered with SP (AS + SP) in March 2003. The effects of this change in case management on malaria parasite infection in the vectors were analysed. RESULTS: Plasmodium falciparum entomological inoculation
Immunogenicity of a virosomally-formulated <em>Plasmodium falciparum</em> GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to... (Publications)
against all three formulations exhibited cross-reactivity with in vitro cultivated blood-stage parasites. Immunofluorescence and immunoblot competition experiments showed that both components of the hybrid [...] CONCLUSION: A virosomal formulation of the chimeric protein GMZ2 induced P. falciparum blood stage parasite cross-reactive IgG responses specific for both MSP3 and GLURP. GMZ2 thus represents a candidate
In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile... (Publications)
BACKGROUND: In sub-Saharan Africa, parasitic diseases and low bioavailable iron intake are major causes of anemia. Anemia results from inflammation, preventing iron recycling and decreasing dietary iron [...] utilization. These findings provide insights into the iron metabolism and the etiology of anemia in parasitic infections. This trial was registered at clinicaltrials.gov as NCT01163877
