Heterogeneities in the transmission of infectious agents: implications for the design of control programs (Publications)
known as the 20/80 rule. The rule applies to a variety of disease systems, including vector-borne parasites and sexually transmitted pathogens. The rule implies that control programs targeted at the "core"
Anilinoquinoline based inhibitors of trypanosomatid proliferation (Publications)
leishmaniasis). In addition, sub-micromolar compounds were identified that inhibit proliferation of the parasites that cause African animal trypanosomiasis, T. congolense and T. vivax. We have found that this set
Methionine-containing rhabdopeptide/xenortide-like peptides from heterologous expression of the biosynthetic gene cluster <em>kj12ABC</em> in... (Publications)
acids such as valine, leucine, or phenylalanine revealed good activities of 2-7 against protozoan parasites and no cytotoxicity against mammalian L6 cells.
Identification of steroid-like natural products as antiplasmodial agents by 2D and 3D similarity-based virtual screening (Publications)
The virtual screening strategy resulted in the identification of nine new compounds that inhibited parasite growth with IC50 values of
<em>In vitro </em>drug efficacy testing against <em>Trypanosoma brucei</em> (Publications)
human African trypanosomiasis has demonstrated the high predictive value of cell-based assays for parasite chemotherapy. Here we describe three in vitro drug susceptibility tests with Trypanosoma brucei
Indigenous <em>Plasmodium malariae</em> infection in an endemic population at the Thai-Myanmar border (Publications)
Plasmodium malariae is a neglected malaria parasite. It has wide geographic distribution and, although often associated with mild malaria, is linked to a high burden of anemia and nephrotic syndromes.
Studies on <em>Trypanosoma (Nannomonas) congolense</em> IV. Experimental immunization of mice against tsetse fly challenge (Publications)
this same stock. The immunity was stock-specific and directed against the metacyclic forms of the parasite, but was short-lived
Spiroindolones, a potent compound class for the treatment of malaria (Publications)
Spiroindolones rapidly inhibit protein synthesis in P. falciparum, an effect that is ablated in parasites bearing nonsynonymous mutations in the gene encoding the P-type cation-transporter ATPase4 (PfATP4)
Novel diamidines with activity against <em>Babesia divergens</em> <em>in vitro</em> and <em>Babesia microti in vivo</em> (Publications)
diminazene and pentamidine, are well-studied chemotherapeutic agents with significant activity against parasitic diseases. The in vitro activities of novel diamidine compounds against the Babesia divergens strains
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described... (Publications)
while 5-7 displayed moderately potent antiplasmodial activities against Plasmodium falciparum parasites
