Malawi Malaria Indicator Survey Quality Assurance Services (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/malawi-malaria-indicator-survey-quality-assurance-services
Malaria indicator surveys are an important source of data on disease burden (parasite prevalence, fever prevalence, etc), and coverage of malaria prevention and case management interventions, particularly
In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in <em>Plasmodium</em> models (Publications)
Furthermore, the compound appeared to be equally efficacious on drug-resistant and drug-sensitive parasite strains. In vivo, SSJ-183 showed a rapid onset of action, comparable to that seen for the antimalarial
Imidazolopiperazines: hit to lead optimization of new antimalarial agents (Publications)
is discussed, focusing on optimization of cellular potency against wild-type and drug resistant parasites and improvement of physiochemical and pharmacokinetic properties. The lead compounds in this series
Age and seasonal variation in the transition rates and detectability of <em>Plasmodium falciparum</em> malaria (Publications)
infections because of the difficulty of distinguishing persisting infections from new ones, and because parasite densities are often transiently below the limit of detection. We recently developed a dynamic model
Spatially explicit <em>Schistosoma</em> infection risk in eastern Africa using Bayesian geostatistical modelling (Publications)
Schistosomiasis remains one of the most prevalent parasitic diseases in the tropics and subtropics, but current statistics are outdated due to demographic and ecological transformations and ongoing control
Strategic roles for behaviour change communication in a changing malaria landscape (Publications)
interventions, and 4) to explain changing diagnostic concerns (e.g. increasing false negatives as parasite density and multiplicity of infections fall) and treatment guidelines. The purpose of this commentary
Selective anti-leishmanial strathclyde minor groove binders using an N-oxide tail-group modification (Publications)
agent that have been shown to have potent activity against various bacteria, viruses, fungi and parasites. Herein, it is shown that S-MGBs have potent activity against L. donovani, and that an N-oxide
Structure-activity relationships of cinnamate ester analogues as potent antiprotozoal agents (Publications)
pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro-aromatic derivatives suggested
Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids (Publications)
2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes possess activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica
Naturally occurring cardenolides affecting <em>Schistosoma mansoni</em> (Publications)
micromolar activity of several cardenolides against newly transformed schistosomula (NTS) of the parasitic flatworm Schistosoma mansoni in a small compound screen including different substance classes of
