Selective anti-leishmanial strathclyde minor groove binders using an N-oxide tail-group modification (Publications)
agent that have been shown to have potent activity against various bacteria, viruses, fungi and parasites. Herein, it is shown that S-MGBs have potent activity against L. donovani, and that an N-oxide
Spatially explicit <em>Schistosoma</em> infection risk in eastern Africa using Bayesian geostatistical modelling (Publications)
Schistosomiasis remains one of the most prevalent parasitic diseases in the tropics and subtropics, but current statistics are outdated due to demographic and ecological transformations and ongoing control
In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in <em>Plasmodium</em> models (Publications)
Furthermore, the compound appeared to be equally efficacious on drug-resistant and drug-sensitive parasite strains. In vivo, SSJ-183 showed a rapid onset of action, comparable to that seen for the antimalarial
Cytotoxic benzil and coumestan derivatives from <em>Tephrosia calophylla</em> (Publications)
cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC(50) of 5.00 (RAW) and 2.90microM
Imidazolopiperazines: hit to lead optimization of new antimalarial agents (Publications)
is discussed, focusing on optimization of cellular potency against wild-type and drug resistant parasites and improvement of physiochemical and pharmacokinetic properties. The lead compounds in this series
Age and seasonal variation in the transition rates and detectability of <em>Plasmodium falciparum</em> malaria (Publications)
infections because of the difficulty of distinguishing persisting infections from new ones, and because parasite densities are often transiently below the limit of detection. We recently developed a dynamic model
Chicken egg yolk antibodies (IgY) for detecting circulating antigens of <em>Schistosoma japonicum</em> (Publications)
sera from healthy persons gave a positive response. Cross-reactions with antibodies to nine other parasites were rare. CONCLUSION: The developed immunoassay is reasonably sensitive and specific. It could
Chagas disease in Switzerland: current situation, challenges and opportunities (Publications)
Chagas disease is a parasitic infection found mainly in continental Latin America. However, it is now present globally due to increasing international mobility and its lifelong persistence in the absence
Strategic roles for behaviour change communication in a changing malaria landscape (Publications)
interventions, and 4) to explain changing diagnostic concerns (e.g. increasing false negatives as parasite density and multiplicity of infections fall) and treatment guidelines. The purpose of this commentary
Peter Odermatt Receives Award from the Government of Lao PDR (News)
https://www.swisstph.ch/en/news/news-detail/news/peter-odermatt-receives-award-from-the-government-of-lao-pdr
structure. Strong links with Lao PDR Swiss TPH has been active in Lao PDR in controlling different parasitic worm infections for more than two decades and continues to collaborate closely with partners such
