Heritability of gastrointestinal nematode faecal egg counts in West African village N'Dama cattle and its relation to age (Publications)
earlier suggestions that genetic control of faecal egg counts is most effective during periods of low parasite transmission. There was a significant (p
<em>In vitro</em> activity of anti-malarial ozonides against an artemisinin-resistant isolate (Publications)
ozonides were highly effective against the dihydroartemisinin-resistant P. falciparum Cam3.IR539T parasites, showing a per cent survival ranging from
Is fever a good sign for clinical malaria in surveys of endemic communities? (Publications)
morbidity was defined to be any current self- or parentally reported illness associated with malaria parasite densities higher than those in healthy individuals. Without diagnosis of individual episodes, p
MAP kinase kinase 1 (MKK1) is essential for transmission of <em>Trypanosoma brucei</em> by <em>Glossina morsitans</em> (Publications)
colonising the salivary glands. Transformation of null mutants with an ectopic copy of MKK1 enabled parasites to complete the life cycle in tsetse and infect mice. This is the first example of a gene that is
Epidémiologie des helminthoses gastro-intestinales des petits ruminants dans la zone sylvo-pastorale au Sénégal (Publications)
(Moniezia expansa, Cysticercus tenuicollis) and 9 nematodes were identified. The most important parasite in sheep was Haemonchus contortus while Trichostrongylus colubriformis predominated in goats. The
Chemically diverse <em>S. mansoni</em> HDAC8 inhibitors reduced viability in worm larval and adult stages (Publications)
displayed selectivity over the human deacetylases and some exhibited very low or no activity against parasite larvae and/or adult worms. We report here the in vitro enzyme and biological activity of a small
Current antifilarial drugs - mechanisms of action (Publications)
Filarial parasites of humans and animals represent a heterogeneous group of pathogenic nematodes, interacting throughout their life cycles with two hosts and, for most species, a bacterial endosymbiont
Limonoid orthoacetates and antiprotozoal compounds from the roots of<em> Pseudocedrela kotschyi</em> (Publications)
crude extract and the two gedunin derivatives exhibited good in vitro activity against all of these parasites
<em>Trypanosoma brucei </em>CTP synthetase: a target for the treatment of African sleeping sickness (Publications)
eucine (DON) and alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin) reduced the parasite CTP levels even further and inhibited trypanosome proliferation in vitro and in T. brucei-infected
Composition and stage dynamics of mitochondrial complexes in<em> Plasmodium falciparum</em> (Publications)
which only represent a fraction of eukaryotic diversity. The unusual mitochondrion of malaria parasites is a validated drug target but remains poorly understood. Here, we apply complexome profiling to
