Niclosamide is active <em>in vitro</em> against mycetoma pathogens (Publications)
Redox-active drugs are the mainstay of parasite chemotherapy. To assess their repurposing potential for eumycetoma, we have tested a set of nitroheterocycles and peroxides in vitro against two isolates
<em>Theileria annulata</em> sporozoite surface antigen expressed in Escherichia coli elicits neutralizing antibody (Publications)
Theileria annulata is an economically important protozoan parasite that threatens an estimated 250 million cattle with the disease tropical theileriosis. Development of a defined subunit vaccine is one
Staphylococcal disease in Africa: another neglected 'tropical' disease (Publications)
The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gra
<em>Trypanosoma brucei </em>CTP synthetase: a target for the treatment of African sleeping sickness (Publications)
eucine (DON) and alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin) reduced the parasite CTP levels even further and inhibited trypanosome proliferation in vitro and in T. brucei-infected
Limonoid orthoacetates and antiprotozoal compounds from the roots of<em> Pseudocedrela kotschyi</em> (Publications)
crude extract and the two gedunin derivatives exhibited good in vitro activity against all of these parasites
Phytochemical study and antiprotozoal activity of compounds isolated from <em>Thalia geniculata</em> (Publications)
(Marantaceae) is an African medicinal plant traditionally used in Benin to treat malaria and other parasitic diseases. There is little ethnobotanical and almost no chemical information available for this species
The ultrastructure of cultured <em>Plasmodium gallinaceum </em>ookinetes: a comparison of intact stages with forms damaged by extracts from blood fed,... (Publications)
Golgi-like structures and lysosomes can be observed. After exposure to A. aegypti extracts the parasites exhibit signs of severe cell damage and degeneration, such as disintegration and vacuolization of
Selamectin is the avermectin with the best potential for Buruli ulcer treatment (Publications)
A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy. A panel containing nearly all
The epidemiology of residual <em>Plasmodium falciparum</em> malaria transmission and infection burden in an African city with high coverage of... (Publications)
of 2012. METHODS: Three rounds of city-wide, cluster-sampled cross-sectional surveys of malaria parasite infection status, spanning 2010 to 2012, were complemented by two series of high-resolution, lo
The impact of indoor residual spraying with malathion on malaria in refugee camps in eastern Sudan (Publications)
examined harboured sporozoites. Blood samples of 83 putative malaria patients were examined for parasites by PCR. Mortality rates in the 3 months following spraying were significantly lower in sprayed camps
