Human African trypanosomiasis: pharmacological re-engagement with a neglected disease (Publications)
against the disease are unsatisfactory for a number of reasons. HAT has two stages. In stage 1 the parasites proliferate in the haemolymphatic system. In stage 2 they invade the central nervous system and
Comparison of the Flotac-400 dual technique and the formalin-ether concentration technique for the diagnosis of human intestinal protozoa infection (Publications)
There is a need for accurate diagnosis of intestinal parasite infections in humans, but currently available copromicroscopic techniques have shortcomings, such as low sensitivity. We compared the diagnostic
<em>ent</em>-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the... (Publications)
and chiroptical methods. Biological activities of these alkaloids against different protozoan parasites are described
Chemically diverse <em>S. mansoni</em> HDAC8 inhibitors reduced viability in worm larval and adult stages (Publications)
displayed selectivity over the human deacetylases and some exhibited very low or no activity against parasite larvae and/or adult worms. We report here the in vitro enzyme and biological activity of a small
Translation of liver stage activity of M5717, a <em>Plasmodium</em> elongation factor 2 inhibitor: from bench to bedside (Publications)
factor 2 inhibitor, was assessed in vitro and in vivo with readily accessible Plasmodium berghei parasites. In an animal refinement, reduction, replacement approach, the in vitro IC99 value was used to feed
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for Human African Trypanosomiasis (HAT) (Publications)
brucei , 7 nM for T. b. rhodesiense , and 2 nM for T. b. gambiense ) with excellent selectivity for parasite cells relative to mammalian cell lines (EC50 > 25 ?M). In addition compound 17b displayed suitable
Is fever a good sign for clinical malaria in surveys of endemic communities? (Publications)
morbidity was defined to be any current self- or parentally reported illness associated with malaria parasite densities higher than those in healthy individuals. Without diagnosis of individual episodes, p
Novel 3-nitro-1<em>H</em>-1,2,4-triazole-based piperazines a nd 2-amino-1,3-benzothiazoles as antichagasic agents (Publications)
demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. In the present work we further expanded our research by evaluating in vitro the
Engineered synthetic virus-like particles and their use in vaccine delivery (Publications)
humoral immune responses in mice and rabbits, including antibodies able to cross-react with the parasite, thereby, supporting the potential value of this delivery system in synthetic vaccine design
Treatment of acute uncomplicated <em>Falciparum</em> malaria with artemether-lumefantrine in nonimmune populations: a safety, efficacy, and... (Publications)
cure rate at 28 days was 96.0% for the per protocol population (119/124 patients). Median times to parasite clearance and fever clearance were 41.5 and 36.8 hours, respectively. No patient had gametocytes
